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Meds and recreational drug use
Oct 5, 2003

I know you have been asked this many times before as I have read in the archives. But I was wondering about dangers of crystal with my current meds, epivir, viread, and viramune. Can you tell me what risks I may have with the interaction of this combo and recreational crystal use?

Response from Dr. Conway

You raise an issue that is very important to me, namely the use of HAART in people who use recreational drugs. I feel VERY strongly that such use is NOT a contraindication to HAART. The best-known interaction is methadone with drugs like Viramune, with Viramune causing a more rapid clearance of methadone, and potentially causing withdrawal. This can be addressed quite easily by increasing the methadone dose to prevent this.

Otherwise, you can assume that Viramune may accelerate the clearance of a number of recreational drugs...this will not cause toxicity, but will reduce the "potency" of these drugs.

Viread is an interesting compound, and all the drug interactions have not been worked out. I would advise caution here, especially with such heterogeneous substances as crystal.

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