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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Oct 3, 2003

Dear Docs, I have been possitive for 18 years and had my first AIDS diagnosis back in 1994. I have been on antiviral therapy since 1990 with out any breaks until this summer. Against my doctor's advice, I decided to go off my drugs for 12 weeks. I felt better than I ever had in years. Although I am resistant to every drug on the market I have just decided to go back on the drugs because my CD4's dropped to 79 and my viral load is over 100,000. I am back on 8 drugs now and feeling miserable again. This is all just background.

Anyway, 6 months ago I developed very chronic fatigue with anemia. My doctor thought that it was the result of AZT via Combivir. He took me off the medication but my anemia persisted. He then put me on Procrit and have been on it ever since. With out the Procrit my hemaglobin is at 8.5, with it I can't seem to break the 11.1 mark. Along with all of this I have developed severe constipation, abdominal pain, terrible bloting, and a discomfort all the time. Besides a diet high in fiber, I am also taking Metamucil, Sennekot S, and Lactulose, plus I drink over a gallon of water aday. And even with all this my constipation persists. My doctor just scratches his head about it and really never addresses the issue.

Is there possibly something else going on? Also I was told that my red blood cells are abnormally small and underdeveloped and I do have a family history of colon cancer. I had a colonoscopy 2 years ago and had several polyps removed but they were benign. My age is 44. So what is going on? Please tell me what to do next.

Thank You. G.O. In Minneapolis,MN

Response from Dr. Boyle

The gastrointestional symptoms you mention, including the constipation and bloating, can be due to many things. The list would include your diet, the medications you are taking, limited gastrointestinal movement or motility (which can occur in patients with AIDS), and a bowel obstruction. You should discuss these with your doctor and arrive at a plan for finding what is causing your problem. If he can't come up with anything, then you should see a gastroenterologist for further evaluation. In the meantime, you might try a stimulant/softener such as peri-colace and/or Reglan, a medication that helps with nausea and also increases gastrointestinal motility.

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Hamstring soreness and tightness a side effect?

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