Sep 12, 2003
I heard that there have been changes to the patient information for Viread and that new information indicates that Viread may be taken without regard to food. Do you know what other changes were made recently?
Response from Dr. Conway
It has always been correct that administration of tenofovir with a high fat meal increases total drug exposure by up to 40% and peak drug levels by 10-15%. The clinical significance of these values remains unclear. In many settings where linking of tenofovir to food intake was not controlled, there did not appear to be any change in drug efficacy. In our clinic, we do not mandate that the drug be taken with food, and have not had any issues with efficacy of tenofovir-based regimens.
With respect to side effects, there are a number of anecdotal reports of hair loss associated with tenofovir use. It will be interesting to see if the reports of this occurence become more frequent.
More importantly,some have alleged that tenofovir is nephrotoxic. However, when this information is reviewed with a critical eye, it does not stand up to scrutiny, as most of the supposed rises in serum creatinine return to normal on re-testing while not modifying drug therapy.
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