HIV Drugs, Cholesterol, Diabetes
Aug 2, 2003
I've been positive for almost 20 years, was successfully being treated by PIs until last year, when my lipase level jumped to 600, yet with no pancreatitis symptoms. At the same time, my regimen of PIs and D4t/DDI stopped working. Since then, I've been on a heavy regimen of invirase, crix, norvir, plus viread and ziagen. I'm resistant to most HIV meds. Other than side effects of bloating, gas, and major fat loss, my major concern is now elevated cholesterol, triglyceride and glucose leveld. I tried taking pravocol (ineffective), then lipitor (suffered severe muscle pain) for the lipids, and I take glucophage for the diabetes. Although I feel fine, I am now 55, have a history of heart disease in my family, and have seen a cardiologist, who gave me a clean bill of health. However, I feel like a walking time bomb. I know it's all about reaching a balance, but I feel I'm playing with fire on both sides. My T cells are now 325 and viral load not detectable. Would you suggest modifying my HIV regimen? Or any ideas for helping this 'balance'? My weight has dropped from 185 to 160 in less than a year, btw.
Response from Dr. Henry
Your HIV therapy options are highly dependent on which (if any) drugs your HIV virus is sensitive to and you can tolerate OK. Trying to use atazanvir instead of indinavir might help the lipids some. Careful attention to diet/exercise over time can help. Fish oil and fish oil might also be helpful. KH
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