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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Meds Simplification
Jul 17, 2003

I'm currently taking combivir, viramune and viread. My viral load is undetectable and my t-cells are in the 700s. My doctor said that I will more than likely be on this regimen with great results indefinately. I keep hearing about these "one-a-day" pills. Is there anything I can take to simplify my regimen or should I stick with what I'm doing?

Response from Dr. Henry

There is controversy about whether once a day dosing/drugs offer any significant advantage over twice a day. Viramune twice a day is probably not as good as twice a day. Sustiva, 3TC, FTC, Viread, abacavir, D4T, ddI, and atazanavir are all once a day meds. If you are tolerating your current meds well there is no compelling reason to switch. Some might prefer a strategy using only NRTIs to save another class (NNRTIs such as Sustiva or Viramune) for later. If you have never failed a regimen and are highly adherent then the per year failure rate for a good 3 or 4 drug regimen appears low (? < 5%). KH

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