In your opinion, what is the best treatment for neuropathy?

The best treatment is to stop the cause of it, i.e., if its HIV to suppress it, if its a drug to stop it or reduce it, etc. Sometimes elimination of the cause is not possible or the neuropathy persists even after the cause has been removed and medications need to be used to control the neuropathy. Non-steroidal drugs such as ibuprofen, etc., can help with the pain, but sometimes the pain is so great that opioid drugs are required. Topical anesthetic agents have also been tried, with some success. Lamictal (lamotrigine) and Neurontin (gabapentin) can also help: Some studies have demonstrated their efficacy in neuropathy (not all of which involved HIV neuropathy) and some of my patients have done extremely well with these agents. Studies (and my experience) indicate that Elavil (amitriptyline), another agent commonly prescribed for neuropathy, is not very helpful. Finally, there is limited data supporting the use of acetyl-L-carnitine.