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T-20, one drug or cocktail?
Mar 11, 2003

Hi Docs, I would like to know if the drugs that are currently being developed/researched are cocktail drugs or just single drugs e.g I've just read that T-20 is in stage 3 of trials. How many more stages before we can know whether or not it is approved? If it does get approved, will it be available on its own or will it be used with other existing drugs? And what if one has failed the existing drugs? Thank you

Response from Dr. Boyle

Enfuvirtide (T-20) will likely be approved in the next few months. It must be used in combination with other antiretrovirals, i.e., in a "cocktail", otherwise resistance to T-20 develops quickly. Some patients who have "failed" the exisiting drugs, can still gain benefit from T-20 when it is used in combination with other antiretrovirals that are put together to form an "optimized background", but if there are no other drugs to support it, the beneficial effect is likely to be short lived.



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