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Fusion Inhibitors
Feb 19, 2003

Can you shed any light on what, if any, of the preliminary reports on fusion inhibitors may include as far as side effects? I guess I am assuming they have done some human trials??

Response from Dr. Henry

T-20 = Fuzeon is the only fusion inhibitor soon to be more widely available. Since it acts outside of cells (blocking fusion) its toxicity would be expected to be low and that has been the case in major clinical trials conducted to date. The major adverse reaction involves pain/discomfort at the injection site (must be injected subcuteously twice a day) which is severe enough to cause about 3-5% of patients to quit taking the drug. Other side effect rates have been low during the first 6-12 months of follow-up. KH

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