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Feb 3, 2003

My Dr. wants to start me on sandostatin for uncontrollable diarrhea. I am unable to find information on this drug. Could you please tell me dosage/side effects/what-if any-other uses this med is used for/effectiveness/is this drug of choice/etc. Thank you.

Response from Dr. Henry

Sandostatin is octretide which acts to inhibit many hormones associated with diarrhea. I have had some success with it in cases of refractory diarrhea. It is given as a shot either subcutaneously or intravenously. The most common side effects are nausea, injection site reactions, bloating, increased gas and glucose problems. It is dosed starting at 50-100 mcg 1-3 X day with doses ranging as high as 1000mcg/day or more. It is costly (500 mcg/ml ampule costs $76. Again, I hae had some modest success with it in cases where diarrhea persisted despite all efforts and no cause that could be further treated was present. KH

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