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Ankles and peripheral neuropathy
Jan 21, 2003

I am taking Tenofovir, Stocrin, 3tc and Abacavir. I have moderately severe peripheral neuropathy (PN) in both legs/feet for which I am taking no treatment.

Over the past year I have been noticing that both my ankle and toe joints are becoming increasing stiff. When I first put weight on them after standing, both the ankle and toe joints crack loudly many times. My calf muscles are also very tight indeed. I have read (though goodness knows where) that PN can cause joint collapse. Have you had any similar problems in your experience - what could this be?

Many thanks for any suggestions.


Response from Dr. Henry

In some patients peripheral neuropathy can be associated with muscle stiffness which can translate into stiffer joints. The 3TC can aggravate peripheral neuropathy. AN evaluation by a neurologist can sometimes sort out the possible etiology (HIV versus drugs versus other conditions). Treatment to relieve the symptoms is sometimes helpful. Consideration of massage/acupuncture or other alternative approaches (see can be useful for some patients. Joint damage/collapse is usually not a problem but occcasionally patients can damage their feet if they lack any sensation whatsoever (see that in syphilis and diabetes for example). KH

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