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CYP 450 enzimes
Nov 14, 2002

Dear doctors Alprazolam (xanax) is a substrate of CYP 450 3A4. Sustiva that is inibitor/inductor of this liver enzimes should be create interaction like this psicotrope substance? And what is the difference from substrate-inducer-inibitor? Thanks Marcello

Response from Dr. Boyle

Although the effect of Sustiva on benzodiazepines is highly variable, Sustiva generally leads to increased levels of benzodiazepines, and these should be used with caution in patients taking Sustiva. Data have shown that lorazepam levels are not changed much by sustiva and no dose adjustment is required; however, 2 benzodiazepines (midazolam and triazolam) are not to be coadministered with Sustiva. I am not aware of any data that specifically addresses the use of alprazolam and you should discuss this issue with your doctor.

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