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Nov 14, 2002

Does ribavirin cross the blood brain barrier? Does Interferon? And what about in combo? Is a person infected with a CNS virus like herpes zoster more likely to have their HCV or HIV infection enter the brain?

Response from Dr. Henry

Ribavirin slowly diffuses into the brain (CSF) reported to reach 70% of plasma levels after 4-7 weeks of treatment. Their is no data that I am aware of that says that a CNS virus like herpes zoster increases ribavirin levels in the cerebrospinal fluid. KH

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