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Lipoatrophy=Cushing's Syndrome???
Sep 25, 2002

Dr. Henry, Thanks for your great answers. Recently I saw a presentation concerning "Cushing's Syndrome". The "look" of the subject i.e. belly and hump and the symptoms looked just like lipoatrophy and it also was supposed to cause bone loss just like those of us who have gotten osteopenia and/or avascular necrosis. The doctor spoke of "excess cortisol" as the culprit. Could we patients who have lipoatrophy have too much cortisol going on??? Thanks again.

Response from Dr. Henry

Good question. Several investigators have looked for evidence of Cushing's disease in the setting of lipodystrophy and have been unable to find it. One group looks at the ratio of several cortisol like compounds and thinks there is an abnormality but most experts are not convinced about that approach. Bottom line--no good evidence that the link exists though the syndromes share some features you noted. KH

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