Sep 20, 2002
Can you please confirm what I've heard, which is that PIs grow fat cells in a petri dish. If this is so, what is going on with lipoatrophy and people using PIs.
Response from Dr. Henry
There have been some lab dish type observations involving PIs that suggest they can disrupt fat cell metabolism/activity. Recent data from Barcelona (the FRAN study) suggested that fat loss is the problem most linked to HIV infection and/or treatment. The issue of fat gain is more complex since fat gain in some regions of the body is already occuring widely in the general US population. Clinical useful information about the role of PIs in general or specific PIs and fat changes is still lacking unfortunately.KH
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