The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

Drugs that cross blood/brain barrier
Sep 1, 2002

Is there information regarding the effectiveness of the HIV drugs to successfully cross the blood/brain barrier. I have read that some drugs do not while others are more effective. Can the virus be gone from the blood yet still be very active in the brain? Which drugs do you recommend?

Response from Dr. Henry

The NNRTI class (esp nevirapine and efavirenz) cross the blood brain barrier well. There is good experience with AZT crossing the blood brain barrier and some with 3TC. The other NRTIs have been less well studied. Of the PIs, indinavir with its low protein binding has demonstrated reasonably CSF levels. It is possible to have cleared the virus from the plasma abut not the CSF but ordinarily the two compartments do mirror each other (with some exceptions well documented). KH

thyroid/low basal temperature

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint