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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Triglycerides are 592
Jul 3, 2002

I've had HIV since 1986. I'm 49, 160#, 5'8". I was on Agnerase, Norvir, Ziagen & Combivir, until June 1. On May 28 I started PegIntron and Rebetol for HCV. I stopped HIV meds due to extreme side effects combined with HCV meds. I stopped all meds on June 30 due to side effects. I'm now anemic and take Procrit injections. Before HCV treatment, T4 649, HIV VL 60, HCV VL 1414000, ALT 65. Now, T4 are 124, HIV VL 75,000, HCV VL 15979, ALT 33. My Trig started going up prior to HCV treatment, last year from 174 steadily to current of 592 (Cholesterol 148, HDL 20, LDL unable to calculate). Heart desease is prevalent in my family. Could the elevated Trig. be due to medications, family history or both? I excercise, but haven't watched my diet to much, although I'm not overweight. I understand that the Cholesterol meds can be bad for my liver. Any suggestions.

Response from Dr. Henry

Lipid abnormalities have been reported in the context of both HIV treatment and HCV treatment and perhaps worse with both. Family history and HIV and/or HCV infection can also contribute to high triglycerides. It definately would be wise to see a nutritionist/exercise counselor to optimize that. Fish oil (1000mg) and a low dose aspirin tablet might be a good idea for starters. Fenofibrate (or gemfibrizole) is pretty good at getting the triglycerides down and has only a modest liver risk (which can be monitored). Niacin (slow-release) may also be effective at getting the triglycerides down. Hopefully you are a non-smoker!

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