SIDE EFFECTS ROLLER COASTER
May 29, 2002
HI, I'VE BEEN POSITIVE FOR 6 YEARS AND JUST BEGAN TAKING TRIZIVIR FOR 2 WEEKS NOW. I STARTED HAVING EXTEME NAUSEA ON DAY 4 AND SINCE THEN ITS BEEN BAD TODAY, MILD TOMORROW, THEN NONE THE NEXT DAY THEN THE CYCLE REPEATS. I FIND THAT I GET NAUSEOUS WHEN ITS NEAR TIME FOR MY NEXT DOSE. IS THIS NORMAL OR DO YOU THINK MAYBE I AM GETTING NAUSEUS IN ANTICIPATION OF THE NAUSEA ITSELF? GENERALLY THOUGH I DONT FEEL AS "WELL" AS I USED TO BEFORE. ALSO I FIND THAT I AM ALWAYS HUNGRY AND ALWAYS WANT TO EAT SINCE STARTING THESE DRUGS. i THINK THIS IS STRANGE.
Response from Dr. Henry
Many patients experience very impressive upper GI symptoms after starting AZT/3TC/abacavir=Trizivir. Most often this is an AZT effect. For most persons this slowly improves over the first 2-4 weeks. Sometimes anti-emetics (such as Compazine, Reglan, or Marinol) are used temporarily. If other symptoms are present such as fever or rash then there would some concern about a possible abacavir reaction (usually gets worse after taking each dose--not before). I suggest providing details to your HIV specialist to sort out! KH
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