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changing medications from crixivan to sustiva because of kidney stones
May 5, 2002

Hi I have been on crixivan for about 7 yrs. before crixivan my viral load was 1,000,000 copies now only 60. Recently I've been having problems with kidney stones (twice) my doctors are thinking about switching me to sustiva. I'm afraid because crixivan has worked so well for me all these years. Can you please gjive me some advise. Thank You. Nancy

Response from Dr. Henry

Studies that have evaluated how patients do when they switch from a PI (such as Crixivan) to a NNRTI (such as Sustiva) have generally found that the switch is successful and that patients prefer the simpler regimen (Sustiva is now available as one pill per day). If you have having problems with kidney stones then a switch is an attractive option. If you previously had failed other regimens (such as ones including nevirapine-another NNRTI) then a switch may not be such a good idea (your HIV specialist should be able to sort that out). KH

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