Specific alcohol question -- NOT toxicity, adherence, or safe sex
Mar 14, 2002
Everything I've read on this forum seems to indicate that moderate (1-2 drinks) alcohol consumption is OK with HIV meds. And that more alcohol means more problems with adherence, safe sex, and, especially, liver/pancreas toxicity. But NOWHERE have I come across any response or data which addresses the issue of whether alcohol reduces the specific efficacy (the antiretroviral activity) of these drugs. Now, I have a job which requires (I'm not complaining!) me to do a lot of after-hours entertaining. On at least three occasions I've had to take my 10 pm Combivir with 2-3 martinis only. (I've rushed home and had food later.) My question is, adherence, safe sex, and toxicity aside -- have I been careless and reduced the potential of these drugs working by doing this. (I've taken a two-week leave and plan to virtually eliminate evening drinking socializing for the remainder of the PEP regimen -- 16 more days.)
Response from Dr. Henry
There is no data that clearly indicates that moderate alcohol use directly impairs the activity of Combivir (the other cautions still apply). KH
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