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PEP (Combivir) side-effects

Mar 8, 2002

I'm on my 4th day of a PEP regimen (lamivudine 150 mg and zidovudine 300 mg, twice a day, 28 days) after a potential exposure (unprotected anal insertive sex). The PEP was started roughly 44 hours after exposure. My question is, apart from the GI system side-effects I'm experiencing (mainly dyspepsia), I also have a sore throat, some coughing, and a blocked nose for part of the day. Could these ENT problems be Combivir-related? Or is this seroconversion occurring already!? I had had a sore throat, feverish feeling the day BEFORE the potential exposure -- could this cough etc simply be a "hangover" from that (and would the drugs exacerbate that)?

Response from Dr. Henry

Those symptoms would be unusual to be due to the Combivir or HIV seroconcersion. Most likely those symptoms are an extension of your pre-existing cold like symptoms are some other upper airway cold or allergic reaction which are very common in the general population. KH

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