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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Neuropathy in feet and general fatigue
Feb 6, 2001

I have been on Viracept and Combivir for over two years quite successfully. However I still experience neuropathy and general fatigue. Anything I can do about these problems? Bob D

Response from Dr. Young

Generalized fatigue can be a side effect of zidovudine (ZDV, AZT) component of Combivir. It may also be the result of anemia (another side effect of ZDV).

The neuropathy that you describe is probably HIV-related, more than medications, since neither Combivir or Viracept are associated with significantly increased risk. We have had some luck with medications to alleviate neuropathic pain- our list includes anti-inflammatories (ibuprofen, Celebrex, Vioxx), gabapentin (Neurontin), Marinol, certain anti-depressants. Some have had success with acupuncture. These symptoms can be very pesky, stay with the therapies and try different adjunctive methods. Good luck- BY

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