|PI giving side effects, - change?
Feb 22, 2002
I have tried Viracept and it was intolerable in the GI tract. I recently tried Kaletra and it reduces viral load well, but also bothers GI tract and keeps me from eating enough. Should I consider switching PIs AGAIN?? THANKS !!
Response from Dr. Henry
Switching off a PI to either a NNRTI (such as Sustiva or Viramune) or to abacavir (Ziagen) often can alleviate side effects like you are experiencing. Whether that is a good idea from the HIV perspective depends on whether you previously had been on those or other drugs and experienced a virologic failure os some sort so that you may harbor a drug resistant virus. You would need to review your treatment history with your HIV doc and then discuss your options. Most HIV docs are pretty comfortable switching off PIs if other good choices are available. KH
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