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Mood changes due to use of Abacavir JB

Dec 19, 2000

Six weeks ago I started taking Ziagen (abacavir), as substitute for D4T, which is suspected of giving me peripheral neuropathy. My other HIV treatments are Nelfinavir & 3TC. Since starting abacavir I've been experiencing unusual mood changes, sometimes feeling euphoric & what I describe as feeling like I'm on speed (although I have never tried "speed")& full of energy, but other times having a sense of futility about life & totally lacking energy or interest. I don't think I'm suffering depression so I find these feelings unusual. My question is: Do you have any evidence or anecdotal reports of abacavir causing unexplained mood changes in people taking it. Hope you can help, best wishes, Peter.

Response from Dr. Bartlett

Peter, I am not aware of mood changes being reported with abacavir, but certainly these drugs can have very individualized side effects. If your symptoms continue I would get together with your health care provider and discuss the options.

John A. Bartlett, M.D.

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