Jan 8, 2001
Started taking Kaletra and Viramuna a couple of months ago and for the most part seem to adjusting well. Many years ago I was taking acyclovir on a regular basis prior to me start any antiv's. More resently I read more and more about new studies stating that Acycolvir could prevent KS & lymphoma. I notice now that I've started retaking the Acyclovir I seam to have a cronic small head aches. Any reason why? Does the Acyclovir dehydrate me?
Response from Dr. Henry
If you were tolerating the acyclovir before it seems unlikely that it is the acyclovir per se. Since the acyclovir is matched with some new drugs maybe there is a drug interaction of some sort going on whcih is expressed as a headache (which can occur in around 2% of patients on long-term acyclovir). If you are a little dehydrated from the Kaletra (perhaps changing your eating habits or increased loose stools) than might contribute. The data regarding acyclovir and prevention of lymphoma is intriguing but not definitive (I would say might apply more to persons with CD4 < perhaps 225. The clearance of acyclovir from the body is kidney dependent so drinking more water might me worth trying to several weeks. KH
Keith Henry, M.D.
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