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About lyphodystrophy
Jan 18, 2001

my wife has this cond. and she is having a hard time ditributing the fat (her body does i mean) she is normally 46 kilos she lost7klos and went down 2 39k's and has now gone up 2 49k's is there any meds.that can help her dist. the excess body fat(SHE IS TAKING CRIXIVAN,DIDANOSINE,HYDROXY UREA,STAVUDINE,RETONIVIR,TRIMETHOPRIM,ACICLOVIR,TRAZADONE,PRAVASTATINA,H.R.T.,QUININE) LOOK FORWARD 2 YOUR REPLY I LIVE IN SCOTLAND NOT IN USA

Response from Dr. Boyle

Human growth hormone has been shown to help decrease breast size and fat pads that some women experience as a part of lipodystrophy. this medication is quite expensive, however, and most of the fat accumulations recur if it is stopped. Metformin is another agent under investigation, but the data is not in yet to say that this is an effective therapy.

She could also consider trying a regimen that eliminates the protease inhibitors and stavudine from her HAART regimen, but most "switch" studies do not show any significant improvement in lipodystrophy although progression may be slowed. Some have tried L-carnitine, riboflavin and other vitamins for lipodystrophy but the data does not show much, if any, benefit. Exercise and diet may also help, but in a limited fashion. BB

Brian Boyle, M.D., J.D.



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