Dec 8, 1998
I am currently on Crixivan, Epivir, and Zerit. So far, so good for about 3 months. I have been drinking a lot of fluids in order to prevent kidney stones from the Crix. I drink approximately 2-3 liters a day of water, iced tea. My bladder has really been getting a workout and is sometimes painful. I also have an enlarged prostate that causes the normal urinary problems especially at night. My question(s): How much fluids is enough to prevent kidney stones? Can I cut down a little? How much do you recommend? Is there a lab test on urine to see if there are large amounts of crystals in the urine. Does Viracept also cause kidney stones? Thanks in advance. BOB
| Response from Dr. Cohen
Hey Bob. Sounds like lotsa Ice Tea. Three quarts is MORE than you need - the recommendation is to drink about 48 ounces a day - that is one and a half quarts. So you can decrease it a bit. And Ice Tea does have caffeine - so you might notice being a bit buzzy with all that caffeine going on...? and there was one report that cranberry juice in particular might decrease the chance of stones by acidifying the urine - since this can help keep the Crix from forming into crystals.
No good urine test to know how well you are doing as far as I know. You can check a urine analysis - but there are no results that predict that you are doing fine or need more water to prevent an impending stone.
And last - this issue in only a problem for Crix. The other PI's - viracept/nelfinavir, saquinavir/fortovase, and norvir/ritonavir - don't have this issue. So if this is more a burden that you can swallow - then you can consider alternatives. We know that those who switch from one med to another are usually - though not always - successful. So switches should be done when you need to - but not just "casually".
Hope that helps. CC
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