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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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PN Questions
Jan 8, 2003

My PN has increased in intensity over the past 1.5 years. Sometimes I even have trouble walking. I hate to changes my meds yet because they are working so well for me. I have three questions: Is PN permanent? Will my current symptoms go away if I change meds? Which meds list PN as a possible side-effect? Thanks for your help!

Response from Dr. Henry

PN has been linked mostly to the D drugs (ddI, d4T, ddc) and less often to 3TC or other Nukes or drugs in other classes. PN is sometimes reversible but not always. Depending on which drugs you are on and your treatment history, often substitutions are made if the PN is felt to be drug related (can also be due to HIV itself, vitamin deficiencies, diabetes and other medical conditions). KH

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