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Atripla & Grapefuit
Jul 22, 2009
Hello,
I'm I bit confused. I've read that if a person is taking Atripla they can absolutely can't either eat or drink any grapefruit or byproduct of grapefruit. Is this true? I know of a HIV+ person who has just started Atripla and they both eat grapefruits and drink grapefruit juice. What the 411 on Atripla and grapefruits?
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Response from Dr. Henry
There is no study to my knowledge that clearly answers that question. There is a theoretical concern about liver metabolism changes from grapefruit that is a real concern when taking protease inhibitors but less so with efavirenz. So data is limited, there is a mild theoretical concern, and I am usually OK with patients eating grapefruit when taking efavirenz though I often monitor more carefully (side effects and evidence for decrease/increased efavirenz levels and looking for unexpected increases in viral levels). KH
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