I am female 39 positive since 1996. I had a long drug holiday of 5 years, I have been taking Kivvexa with Reyataz and Novir for 4 weeks. I am not liking this treatment very much at all. I have glossy sorta yellow eyes no matter how much water I drink they feel strained and sore. I get hot flushes quite often and in generel feeel lousy. I have to go for a TDM (therapeutic drug monitoring) in a few day to see what my levels are. I am hoping i can get off the norvir or something. I felt great before i started treament I feel lousy now. I was on indinvir and combivr for years and never felt like this. Can I go off this regime and switch to something else without scrweing things up. I still have to wait two weeks for the results. I also have4 had reoccuring yeast infections. I am starting to think that I am going downhill, It's been 13 years for me. I am wondering if i am starting to go downhill, havn'et had a new lab result yet. last one was cd4-350 and viral load 19,000

Certainly atazanavir can cause jaundice (yellowing of the eyes). Often many of the annoying side effects experienced when first starting a regimen such as yours may diminish over the first several months. If alternative drugs are available where you are (such as darunavir or fosamprenavir or raltegravir or saquinavir) then a switch may be worth discussing with your HIV doc. I would try to be patient for a while longer though you do sound worriend/miserable but hopefully things will stabilize and then improve. If you have having specific symptoms then sometimes some treatment can be given to help those out. KH