Third times asking about the elisa test result of a ccr5 delta32 mutated person
Aug 24, 2014
Dear Dr. David Wohl,
PLEASE clarify something about the CCR5 delta32 mutation. The HIV virus can't enter T cells - I understand it, but in this case what happen with the viruses - will they die or stay alive in the blood just can't reproduce? If a CCR5 delta32 mutated person gets HIV , the Elisa test will be positive or negative ? Does a CCR5 delta32 mutated person's body make as much antibody against HIV as a normal person's body, despite of the HIV virus can't enter T cells?
PLEASE HELP ME , THANK YOU
Response from Dr. Wohl
HIV that can not enter target cells and reproduce will be destroyed by the immune system. The body is not helpless against HIV. Antibodies and Pac Man like cells can and do eliminate virus even in people who are infected. It is a battle of attrition.
In cases where infection was aborted, such as may be possible in an exposure of a person missing co-receptor, there would not be a full antibody response and tests would remain HIV negative.
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