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Information about early ART therapy delaying antibody production
Jul 5, 2013

Dear Dr. Wohl

First of all thank you very much for offering this service. It is great to know that there is a place for people like me with frequent panic attacks.

More than two years ago I was victim to a date rape incident in London and started PEP within 12 hours. After adhering to the course of PEP for the prescribed period of 28 days I had 3 antibody tests, namely 3, 6 and 15 months post the completion of PEP (i.e. 4,7, 16 months post-exposure). Then I finally thought that I could try to put the experience behind me. However I recently read an article posted by you on the Body entitled "Negative HIV antibody test results among individuals treated with antiretroviral therapy (ART) during acute/early infection" ( http://www.thebodypro.com/content/art16266.html).

Now the information in this article has me seriously worried. If treatment in the window period can prevent anti-body production for so long, could it be that I need to be tested again? Should I be worried? How will I know when my test result is definite? May it be that I don't develop antibodies but still have HIV?

I am scared and I am hurting and I would really appreciate some answers!

Thanks again!

Response from Dr. Wohl

Thanks for writing. Let me reassure you that you are not HIV+. The article I wrote in 2004 reported on a paper that looked at HIV INFECTED people who started HIV therapy early in their infection (weeks to months) and then stopped their meds. These were not PEP cases. A few had delayed antibody responses but several had indeterminate results (not negative) and all had detectable HIV after they stopped their HIV therapy.

Your repeated negative HIV testing demonstrates that you are definitely not HIV infected.

DW



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