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CCR5 - HIV testing
Jun 7, 2013

Dr. Wohl:

What would be the standard HIV ELISA/WB/PCR test results from someone with a CCR5 delta 32 partial mutation actually exposed to HIV ? How much longer could this anomaly delay the detection of Ab/Ag & VL ?

Also assuming someone has the full delta32 mutation and receives the virus, theoretically his chances of developing HIV are lower if the strain is not CXR4. In which case, what would be the results of the HIV tests ?

Response from Dr. Wohl

The presence of the mutation (which leads to less or no receptors that the virus uses to enter T-cells) should not effect the test results. If someone becomes infected, they make HIV antibodies and have p24 present regardless of their CCR5 mutation status.

DW



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