|Positive Elisa & Western Blot but negative PCR-DNA test
Apr 2, 2013
Hello Dr David, Thanks for your valuable insights on HIV prevention and management. I have had a curious question for sometime now, I would like to put it to you (pardom me if it sounds naive!). Say for example if a person has a Positive ELISA and a Positive Western Blot test, however his/her PCR-DNA/RNA tests comes out Negative.Then from what I read in your replies, this would imply that the Elisa/WB tests were false positives.
However can such a diagnostic also imply that actually the infected person developed such robost antibodies for HIV that wiped out the HIV infection itself. If this makes sense then I would like to to know if any research has been carried out in this area to harness/replicate such antibodies.
Kind Regards Sam
| Response from Dr. Wohl
To be clear, a person can be infected with HIV and have an undetectable HIV RNA (viral load). We see this with HIV therapy, of course, but also in so called elite controllers - people who do not cure themselves of infection but who can contain the virus on their own.
They are a rare bunch, these elite controllers, and the evidence suggests that they make a robust immune response to HIV after infection.
False positive Western blots are very very unusual. Therefore, a positive ELISA (EIA) and Western blot for HIV is HIV infection.
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.