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Reyataz and Yellow Eyes

Jun 29, 2011

Hello Dr. I have started Reyataz (300 mg) two weeks ago and from day three I had yellow eyes. I am very unhappy with having to hide my eyes when leaving the house. I would prefer to switch to Perzista but since I have only been taking Reyataz for two weeks my doc doesn't see any urge to change it. Will the yellow in the eyes ever go completly and once gone not come back? I am off sick from work so I would prefer to change asap in order not to have to be off from work longer if I change at a later time. Thanks for your help!!!

Response from Dr. Frascino


Reyataz has many upsides for a protease inhibitor (once-per-day dosing, can sometimes be taken without a Norvir booster, causes less diarrhea than other PIs, doesn't increase cholesterol and triglycerides, etc.); however, one significant downside is yellow eyes! Reyataz increases indirect bilirubin, which for most HIVers is a harmless lab abnormality. But for others it can result in yellowing of the eyes and/or skin (jaundice). These side effects are harmless, but unattractive. Let's face it no one looks good in yellow, right? Most HIVers who develop Reyataz-induced jaundice elect to switch therapy.

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