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hiv drug discovery from high speed supercomputers and drug resistance
May 3, 2011

As you already know, President Obama set aside approx $126 million in this years budget to develop next generation exascale supercomputers. Due to the fact that supercomputers have an unlimited potential to help find solutions to serious problems, from drugs for catastrophic illnesses (HIV/AIDS), military development, green energy solutions, etc...... It seems like $126 million is a ridiculously small amount of money to spend on such an important/ critical application. I think $100 billion dollars per year of funding is more appropriate. was wondering if you agree about the importance and increase of funding. Also, do you think it will it ever be possible to develop drugs that the HIV virus will never be able to form resistance to, or do we already know its physically impossible?

thanks so much, Steve

Response from Dr. Frascino

Hi Steve,

I and all other folks with common sense would support investments in science, research and technology (rather than war and tax cuts for billionaires). Unfortunately the Republicans don't see it that way. Their budget cuts are positively draconian. They not only will defund health care reform, Planned Parenthood and the National Endowment for the Arts, but they will also cut science and research, education (including Pell grants), destroy Medicare, etc. However, tax cuts for billionaires and wasteful defense spending remain sacrosanct in their eyes.

As for antiretrovirals that don't become resistant, yes, it may be possible. However, I believe the cure (functional or complete eradication) will require immune-based therapies as well as antiretrovirals.

Dr. Bob



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