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Does PEP delay seroconversion
Apr 16, 2011

I was prescribed Atripla(Viraday)as PEP for 4 weeks.The course finished on the 7th of March.Since then I've had a negative 6 week ELISA(from the date of exposure).The next test is scheduled for 12 weeks from the day of exposure.Is a 6 week negative ELISA an encouraging sign?Will further testing be warranted after 3 months (from the date of exposure)? If PEP does not delay seroconversion then why do some experts recommend testing after 3 months from the last day of PEP dosage?

Response from Dr. Frascino

Hi,

Yes, a negative post-PEP ELISA at six weeks is very encouraging. The post-PEP HIV testing guidelines recommend HIV-antibody testing at four to six weeks, three months and six months from date of exposure. The CDC recommends a follow-up three-month and six-month test for all significant HIV exposures. Presumably you wouldn't have been given a course of PEP without a significant HIV exposure. Hence the testing guidelines are consistent and not related to any concerns about delayed seroconversion.

Dr. Bob



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