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Should I ask for PEP (HERPES AND HIV TRANSMISSION, 2011)
Mar 16, 2011

Dr. Bob,

Thank you for all you do!

I recently had an experience that has left me sleepless and unable to eat. I was drunk at an up scale strip club and received a private dance from a stripper. She was grinding on my leg and undid my pants. She worked her way onto my penis for 15 seconds and I stopped the dance. I have genital herpes and at the time did not have an outbreak but do have some red marks no open sores or scabs. Also I think I am starting to get one. I dont know what to do and cant focus on work or anything. I feel like Im going into a deep depression. I dont know how I will be able to wait for the 30 days to get my first test?

What are my chances of acquiring HIV in this situation if she does have HIV?

Is the outbreak related to the dancing or could it be a sign of HIV?

It is within the 72 hour window should I receive the PEP treatment?

Thank you in advance and I will be sure to donate to the cause.

Response from Dr. Frascino

Hi,

If Bouncing Betty at the Badda Bing actually grinded her way onto your penis, your HIV-acquisition risk would be unprotected insertive penile-vaginal sex. That it was only for such a brief period of time (15 seconds) would decrease the HIV-transmission risk. However, having a recent genital herpes outbreak (or just having had genital herpes in the past) could potentially increase the HIV-transmission risk. (See below.)

Would it be possible to get Bouncing Betty a rapid HIV test? Results are available in just a few short minutes. If she tests HIV negative, you could relax significantly, because your risk would be decreased to the remote possibility that she was recently infected and still within the window period (HIV infected, but not yet having detectable levels of anti-HIV antibodies).

That BB (Bouncing Betty) was willing to BB (BareBack) is also concerning. You could start PEP and then discontinue it if she tests HIV negative. If you do begin PEP, I'd recommend being followed by an HIV specialist. He'll take a more detailed history, perform a physical exam and advise whether PEP should be continued or not. See below.

Thanks for your support of The Robert James Frascino AIDS Foundation (www.concertedeffort.org). In return I'm sending you my good-luck karma that you are now and will forever be HIV free!

Good luck!

Dr. Bob

Herpes and HIV Transmission Revisited Nov 4, 2010

Dear Dr. Bob:

I sent a version of this following query to you a couple weeks ago, but no reply from you. I realize you are extremely busy so I will try again. I was the one that posted the query over a year ago about the new research which seemed to indicate that even already healed herpes lesions could transmit HIV infection. Is there any new research/data/information on this topic? Do you have an opinion yourself based on your many years experience with the virus whether this sort of transmission is likely to occur?? Put another way, are you aware of situations where HIV infected couples (at least one with HIV and at least one with herpes) consistently used condoms, but still passed the virus between them? Thanks as always for your help. From: Trying to be careful in Asia

Response from Dr. Frascino

Hello Trying To Be Careful In Asia,

I'm not aware of any new information on this front. The research seems quite convincing that even treated/healed HSV-2 infections provide a local cellular environment conducive to HIV transmission. How often this occurs would be difficult to determine, as there are many confounding variables. I'll reprint below some information from the archives discussing what we know so far. Stay tuned to The Body. We'll keep you updated as additional information becomes available.

Dr. Bob

U.S. National Institute of Allergy and Infectious Diseases Press Release Scientists Learn Why Even Treated Genital Herpes Sores Boost the Risk of HIV Infection

August 2, 2009

New research helps explain why infection with herpes simplex virus-2 (HSV-2), which causes genital herpes, increases the risk for HIV infection even after successful treatment heals the genital skin sores and breaks that often result from HSV-2.

Scientists have uncovered details of an immune-cell environment conducive to HIV infection that persists at the location of HSV-2 genital skin lesions long after they have been treated with oral doses of the drug acyclovir and have healed and the skin appears normal. These findings are published in the advance online edition of Nature Medicine on Aug. 2.

Led by Lawrence Corey, M.D., and Jia Zhu, Ph.D., of the Fred Hutchinson Cancer Research Center and Anna Wald, M.D., M.P.H., of the University of Washington, both in Seattle, the study was funded mainly by the National Institute of Allergy and Infectious Diseases (NIAID) with support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, both part of the National Institutes of Health.

"The findings of this study mark an important step toward understanding why HSV-2 infection increases the risk of acquiring HIV and why acyclovir treatment does not reduce that risk," says NIAID Director Anthony S. Fauci, M.D. "Understanding that even treated HSV-2 infections provide a cellular environment conducive to HIV infection suggests new directions for HIV prevention research, including more powerful anti-HSV therapies and ideally an HSV-2 vaccine."

One of the most common sexually transmitted infections worldwide, HSV-2 is associated with a two- to three-fold increased risk for HIV infection. Some HSV-2-infected people have recurring sores and breaks in genital skin, and it has been hypothesized that these lesions account for the higher risk of HIV acquisition. However, recent clinical trials, including an NIAID-funded study completed last year, demonstrated that successful treatment of such genital herpes lesions with the drug acyclovir does not reduce the risk of HIV infection posed by HSV-2. The current study sought to understand why this is so and to test an alternative theory.

"We hypothesized that sores and breaks in the skin from HSV-2 are associated with a long-lasting immune response at those locations, and that the response consists of an influx of cells that are a perfect storm for HIV infection," says Dr. Corey, co-director of the Vaccine and Infectious Diseases Institute at The Hutchinson Center and head of the Virology Division in the Department of Laboratory Medicine at the University of Washington. "We believe HIV gains access to these cells mainly through microscopic breaks in the skin that occur during sex."

The research team took biopsies of genital skin tissue from eight HIV-negative men and women who were infected with HSV-2. These biopsies were taken at multiple time points: when the patients had genital herpes sores and breaks in the skin, when these lesions had healed, and at two, four and eight weeks after healing. The researchers also took biopsies from four of the patients when herpes lesions reappeared and the patients underwent treatment with oral acyclovir. The scientists continued to take biopsies at regular intervals for 20 weeks after the lesions had healed. For comparison, the investigators also took biopsies from genital tissue that did not have herpes lesions from the same patients.

Previous research has demonstrated that immune cells involved in the body's response to infection remain at the site of genital herpes lesions even after they have healed. The scientists conducting the current study made several important findings about the nature of these immune cells. First, they found that CD4+ T cells -- the cells that HIV primarily infects -- populate tissue at the sites of healed genital HSV-2 lesions at concentrations 2 to 37 times greater than in unaffected genital skin. Treatment with acyclovir did not reduce this long-lasting, high concentration of HSV-2-specific CD4+ T cells at the sites of healed herpes lesions.

Second, the scientists discovered that a significant proportion of these CD4+ T cells carried CCR5 or CXCR4, the cell-surface proteins that HIV uses (in addition to CD4+ T cells) to enter cells. The percentage of CD4+ T cells expressing CCR5 during acute HSV-2 infection and after healing of genital sores was twice as high in biopsies from the sites of these sores as from unaffected control skin. Moreover, the level of CCR5 expression in CD4+ T cells at the sites of healed genital herpes lesions was similar for patients who had been treated with acyclovir as for those who had not.

Third, the scientists found a significantly higher concentration of immune cells called dendritic cells with the surface protein called DC-SIGN at the sites of healed genital herpes lesions than in control tissue, whether or not the patient was treated with acyclovir. Dendritic cells with DC-SIGN ferry HIV particles to CD4+ T cells, which the virus infects. The DC-SIGN cells often were near CD4+ T cells at the sites of healed lesions -- an ideal scenario for the rapid spread of HIV infection.

Finally, using biopsies from two study participants, the scientists found laboratory evidence that HIV replicates three to five times as quickly in cultured tissue from the sites of healed HSV-2 lesions than in cultured tissue from control sites.

All four of these findings help explain why people infected with HSV-2 are at greater risk of acquiring HIV than people who are not infected with HSV-2, even after successful acyclovir treatment of genital lesions.

"HSV-2 infection provides a wide surface area and long duration of time for allowing HIV access to more target cells, providing a greater chance for the initial 'spark' of infection," the authors write. This spark likely ignites once HIV penetrates tiny breaks in genital skin that commonly occur during sex. "Additionally," the authors continue, "the close proximity to DC-SIGN-expressing DCs [dendritic cells] is likely to fuel these embers and provide a mechanism for more efficient localized spread of initial infection."

The investigators conclude that reducing the HSV-2-associated risk of HIV infection will require diminishing or eliminating the long-lived immune-cell environment created by HSV-2 infection in the genital tract, ideally through an HSV vaccine. Further, they hypothesize that other sexually transmitted infections (STIs) may create similar cellular environments conducive to HIV infection, explaining why STIs in general are a risk factor for acquiring HIV.

For more information about HIV/AIDS research, visit the NIAID HIV/AIDS portal, and for more information about HSV-2 research, go to NIAID's Genital Herpes Web page.

References Zhu et al. Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nature Medicine DOI: 10.1038/nm2006 (2009). C Celum et al. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet DOI: 10.1016/S0140-6736(08)60920-4 (2008).

Re: Baseline HIV Testing before giving PEP? (PEP AND THE NEED FOR HIV SPECIALIST, 2011)Feb 15, 2011

Thank you so much for your answer Dr. Bob, I will be looking for another HIV specialist to follow up with... but I just wanted to ask you one more thing regarding my original question; Had the baseline HIV test been actually done at the Hospital's Lab, the hospital is entitled to release those results to me right? They wouldn't just tell me that my baseline test was cancelled by the ID specialist if they had indeed performed it right? I am trying to figure out why the lab said that my test was cancelled and never performed and that is why there is no record of it. Can a test be cancelled after being sent to the lab? I am so stress that I have even come to think that the test was performed and it was positive and they are not telling me... irrational I know, but just a lil reassurance from someone that knows the system like you do will not hurt me. Thanks so much again and I will most defiantly be donating at least 100 dollars to help this wonderful service that you guys are running.

David (bellow was your original reply)

...Hi David,

I agree you should have an HIV-antibody baseline test. You can get it done now. If you are HIV infected, the HIV-antibody test will still be positive, even though you are taking PEP.

I'm quite concerned on several levels about the ID doctor's advice. First, there was that confusion about your baseline HIV test. Plus, I'm concerned about his recommendation you get a PCR test done while on PEP to ascertain if you've been infected. That doesn't make much sense! If you are positive or seroconverting to positive, PEP could suppress the HIV plasma viral load to undetectable levels. Consequently, if the ID doc is using the PCR as a diagnostic test at day 15 while you are still on PEP to determine if you are infected, the test could be a "false negative." I would suggest you find a more competent physician preferably an HIV specialist (see below).

Response from Dr. Frascino

Hello David,

I agree it's irrational to think a hospital lab would run an HIV test, determine the results are positive, and then tell you the test was never run or canceled. Why would they do that? It really doesn't matter to the hospital whether you are HIV negative or positive, right? Besides, positive HIV tests must be reported to the local health department by law! There are a number of reasons a test could be canceled after the blood was sent to the lab. The ordering doctor could decide the test is unnecessary; there could be inadequate blood to run the test; there could have been a technical problem (such as a technician dropping the tube of blood or screwing up the test). In these types of situations, the lab would call the physician who ordered the tests and ask if the blood should be redrawn or the test canceled. More than likely your canceled test was the fault of your doctor, not the hospital laboratory. I agree with your decision to consult a more competent physician.

Try not to stress out David. HIV diagnostic testing is not rocket science. It's really very straightforward when carried out appropriately.

Thanks for your tax-deductible donation to The Robert James Frascino AIDS Foundation (www.concertedeffort.org). It's warmly appreciated. In return I'm sending you my good-luck/good-health karma that you are now and will forever be HIV free.

Good luck David.

Dr. Bob

Baseline HIV Testing before giving PEP? (PEP AND THE NEED FOR HIV SPECIALIST, 2011) Feb 6, 2011

Hi there Dr. Frascino,

I understand you must have tons of questions to answer so I'll try to be as short as I can. I went to the ER after a possible exposure, they called the ID doctor that was on call and he decided that my risk were "low-moderate" and warranted PEP. They took some blood and for a complete STD panel including HIV (I had to sign a consent for the HIV test). I was given an initial dose of PEP, a prescription, and told to follow up with the ID doctor in the clinic in a week. They also said that I should be able to get my test results in 3 days from Hospital Records. I picked up my results 3 days after and everything was negative, but the HIV test results was not there; I then contacted Records by phone and asked why my HIV results where not there; the lady said to call back which I did and she explained that she had called the lab and the test where not ready that sometimes those get sent out and take longer. I called a few days later and still no results so I contacted the lab directly and this is the answer that I got "The HIV test was cancelled per request of the ID doctor and that is why there are no results at records, the test was never done." I kind of found that weird but waited for my follow up appointment with the ID doctor. He ordered some liver tests and explained that my risk was low-moderate. I asked him about my baseline HIV test and he said that that was not really needed, that I should do a PCR at 15 days at a location other than the hospital because since I do not have insurance they will not do it there, and if it was negative then I could decide to stop PEP. I told him that I had called the hospital lab and that they had told me that the test was cancelled by him; he looked confused and said "they said that?"

Now here is my question, since this is giving me a lot of stress as it is, I've started to wonder why this happened? did the hospital told him to cancel the test because they don't do hiv testing or because I do not have insurance? I think I am even being delusional and I am wondering if those baseline tests were indeed performed and it was positive and he decided not to tell me since I had already started PEP? I do not know I am freaking out here... What do you think really went on Bob????

Please drop me a much needed lines about this, Thank you so much for your time,

David btw: I am a premed student.

Response from Dr. Frascino

Hi David,

I agree you should have an HIV-antibody baseline test. You can get it done now. If you are HIV infected, the HIV-antibody test will still be positive, even though you are taking PEP.

I'm quite concerned on several levels about the ID doctor's advice. First, there was that confusion about your baseline HIV test. Plus, I'm concerned about his recommendation you get a PCR test done while on PEP to ascertain if you've been infected. That doesn't make much sense! If you are positive or seroconverting to positive, PEP could suppress the HIV plasma viral load to undetectable levels. Consequently, if the ID doc is using the PCR as a diagnostic test at day 15 while you are still on PEP to determine if you are infected, the test could be a "false negative." I would suggest you find a more competent physician preferably an HIV specialist (see below).

Good luck.

Dr. Bob

PEP Dec 27, 2010

I m currently on PEP on day 5 which is Aspen Lamzid,can i still go see the doctor for better medication or this is enough to reduce the chance of being HIV+.My PEP as started 16 hours after exposure.Please help

Response from Dr. Frascino

Hello,

Yes. You should be followed by an HIV physician specialist. She will advise whether your current PEP regimen is adequate or should be modified.

Dr. Bob

Is Altripla only sufficient for PEP (PEP AND THE NEED FOR HIV SPECIALIST, 2010) Mar 30, 2010

Hi Doctor,

I had an sexual encounter with a stranger. He sucked my cock and he ride on my cock just less than 1 min with out condom. i dint feel any pressure in the ass and it was very smooth.I release cum into to his ass.

I was worried, since i dont know the health status of the person, i have consulted emergency medical center after 30 hrs. The doctor gave me Altripla to take one daily before bed time and asked me to take an appointment with an HIV specialist.

I got appointment for date after 14 days from now.

Is Altripla only sufficient for PEP to avoid HIV? Do i need to consult HIV specialist ASAP(urgently)? Is the emergency medical center is giving correct dosage for me ?

Please answer my question ASAP. Thanks in advance.

Response from Dr. Frascino

Hello,

Unsafe sex is risky business!

Atripla is a combination of three antiretroviral drugs -- efavirenz (Sustiva), emtricitabine (Emtriva) and tenofovir (Viread). It's the ultimate in convenience -- the three-in-one tablet is taken just once per day. It is a recommended fixed-dose combination drug for PEP.

It would be helpful if you could see an HIV specialist sooner than 14 days, particularly if you have any difficulty tolerating the therapy (drug side effects or toxicities) or develop any symptoms. A full course of PEP is only 28 days in duration. Perhaps the HIV specialist could work you in sooner or you could see a different specialist. I'll post some information below from the archives regarding PEP and the need to be followed by an HIV specialist.

Good luck.

Dr. Bob

Condom failure - PEP side effects (PEP AND THE NEED FOR HIV SPECIALIST, 2010) Jan 25, 2010

Dear Doc

I am a bisexual male who has always tried to be safe when it comes to sexual partners.

However during recent insertive anal sex with a casual male partner (of unknown HIV status), the condom split. I withdrew less than a minute later without ejaculation. There did not appear to be any blood or mucus, nor were there any cuts, lesions or anything else on me. I am circumcised (in case this makes a difference) - and my most recent HIV test (on the day of the condom failure) was negative.

I started the PEP course within 30 hours. However, almost at the same time as starting the PEP, my tongue became coated with a yellow mucus and I developed night sweats and a very sore throat which only started to subside on day 5 of the course. I have suffered the usual side effects from the PEP drugs (loss of appetite, nausea, etc).

Could this be a sign of seroconversion? Or is it coincidence/side effects from the PEP drugs?

Thanks

Concerned

Response from Dr. Frascino

Hello Concerned,

"Symptoms" that begin 30 hours after a potential HIV exposure would not be caused by HIV seroconversions. The symptoms associated with ARS (acute retroviral syndrome) become manifest two to three weeks after HIV primary infection.

As I have mentioned frequently in this forum, I strongly encourage anyone who has had an HIV exposure significant enough to warrant a course of PEP be followed by an HIV specialist. The specialist would be able to quickly evaluate and address concerns such as those you raise. (See below.)

Dr. Bob

Can PEP meds mimic ARS? (PEP AND THE NEED FOR HIV SPECIALIST, 2009) Aug 22, 2009

Hi Dr. Bob,

Thank you for all you have done and continue to do for people who find themselves scared and bewildered. A twist of humor is also helpful.

I have searched the archives. Simple question, I think, can PEP meds side effects mimic ARS?

Thank you kindly for your answer and please find a donation forthcoming to the foundation.

Regards, Amas

Response from Dr. Frascino

Hi Amas,

Simple question, yes. However, the answer is not quite so simple! HIV acute retroviral syndrome (ARS) symptoms are quite variable from case to case. These symptoms are also "non-specific," which means they can be caused by many different conditions (for instance many underlying conditions can cause fever, rash, malaise, etc.). Post-exposure prophylaxis (PEP) is any combination of antiretroviral drugs used to try to abort an HIV infection following an exposure. Each of these drugs has a wide array of potential side effects. Not everyone uses the same PEP regimen and not every drug has the same side effect profile. So since ARS symptoms are broad, varied and non-specific and since PEP regimens are varied with each component drug having a wide array of potential side effects, it is possible (although not highly likely) that some PEP-related side effects could mimic some HIV ARS symptoms. This is one of the reasons I always recommend (when possible) that folks who have had an HIV exposure significant enough to warrant a course of PEP be followed by an HIV specialist during the 28-day course of treatment. An HIV specialist is best suited to evaluate and manage any symptoms that might arise during a course of PEP. (See below.)

Amas, as you can see, not all simple questions have simple answers.

Dr. Bob

EMS Exposure (PEP AND THE NEED FOR HIV SPECIALIST) Mar 2, 2009

A patient of mine had projectile vomiting and some of it landed in my mouth and eyes. There was no way I could have avoided this. I do not think there is a risk of HIV transmission, however, the hospital put me on Viread and Combivir as a precaution. The patient was homeless, intoxicated, and not forthcoming of his medical history.

What do you think of this situation?

Response from Dr. Frascino

Hi,

Vomitus (like saliva, urine, tears, sweat, nasal mucous and feces) is not considered to be a risk for HIV transmission unless there is visible blood present. PEP was most likely not warranted. As with all people who have had a potential exposure significant enough to begin a PEP regimen, I recommend you be evaluated and followed by an HIV specialist physician. (See below.) He will take a detailed history and advise whether or not PEP should be continued or modified. Also, since you know the potential source patient, he could be contacted and asked to undergo HIV screening.

Good luck.

Dr. Bob

pep and the worst year of my life. (PEP AND THE NEED FOR HIV SPECIALIST) Jul 13, 2008

I'm a bit nervous because I just took PEP and I don't know what the side effects are so maybe you can help out with it.

I've been having pains in my right abdomen for about a month now but my liver enzymes are normal. I'm still a bit scared because it is where my liver is.

Yesterday, I has receptive anal sex with a stranger. I put a condom on him and he was doing what he was doing. Then he said, I THINK SOME ONES COMING, So I look around, there was nobody there and looked behind me. Saw that the condom with lube was on the floor and his zipper was zipped up. Didn't think anything of it. Went home and pooped. I saw a glob of his semen in the toilet and was going to kill myself.

My possible exposure before this one was 4 months ago. It was anal receptive without condom with a guy I barely knew who I can't get in touch with. I came down with flu symptoms and was told to test at 3 months and then 6 months and then a year because I got really sick.

So my result was negative today before I started pep. I wanted to know if my testing window period will change for the sexual encounter that took place 4 months ago or should I trust in a 4 month negative??????

PEP treatment is 1 month.

When should I test again.

Should I stop taking the pep?

Does pep have hiv in it that will effect me if I have previously been exposed(4 months ago), ruining my chances of being negative?

I've had the worst luck any guy can have. I didn't have sex for 4 months and the one day I decided to cruise, I got violated.

Will pep have a bad effect on me if I am infected and don't know it from the 4 month issue?

I know that you're the only one that can answer these questions for me.

Response from Dr. Frascino

Hello,

Why would you think I am the only one who could answer your questions! Your questions are not uncommon or particularly challenging. Any HIV specialist should be able to help. I'm a bit concerned by your first statement, ". . . I just took PEP and I don't know what the side effects are . . . ." The prescribing physician (hopefully an HIV specialist) should have explained potential side effects at the time the medications were recommended. I can't specifically answer this question, because side effects are different from person to person and also the range of potential side effects differs depending on which antiretroviral medications are in the PEP regimen. I'm also concerned about several of your other questions, such as "Does PED have HIV in it?" Questions like this demonstrate a profound lack of understanding of post-exposure prophylaxis and antiretroviral therapy. (The brief response is no, of course these medications do not contain HIV!)

Your multiple concerns clearly demonstrate why I strongly recommend that all folks who have had an HIV exposure significant enough to warrant PEP have an HIV specialist involved in their care. The HIV specialist will:

1. Evaluate and document the HIV risk exposure.

2. Recommend PEP if warranted.

3. If PEP has already been started, the HIV specialist will revise, optimize or suggest discontinuation of the PEP regimen as indicated.

4. Evaluate and manage all PEP-related side effects and toxicities.

5. Evaluate all symptoms, including potential acute retroviral syndrome symptoms, occurring during the course of PEP therapy.

6. Arrange for and interpret post-PEP HIV testing.

My advice to you is to contact an HIV specialist. He or she will specifically address all your concerns in detail. I would also suggest that you be a bit more discerning regarding your sexual partners. When that last jerk said "I THINK SOME ONES COMING," apparently he was talking about himself! If he managed to ditch the condom without your realizing it, you really need to pay more attention to "what he is doing while he's doing what he's doing," particularly when he's "doing" you!

Good luck!

Dr. Bob

ARS or PEP side-effect? Jul 3, 2008

Hi Doc,

Thank God for you and this website! Quite concerned over the following:

I'm on PEP (Kaletra and Truvada) after a potential exposure (4 days ago) and noticed yesterday for a time (and again today) that my face is quite warm and I feel flushed. I have had the usual loose stool, stomach-related side-effects of the meds but I'm REALLY hoping that you can tell me if a slight temperature might also be a side effect and not a result of the "ARS" I see so many here concerned about. Obviously self-diagnosis is a BIG mistake, as is worrying and stressing but I'd very much appreciate your honest opinion.

Many thanks

Response from Dr. Frascino

Hi,

Your question graphically demonstrates the reason I suggest anyone who has had an HIV exposure significant enough to warrant a course of PEP be followed by an HIV specialist. The HIV specialist can document your true degree of HIV risk, optimize PEP regimens, evaluate and manage all PEP-related side effects or toxicities, monitor for and evaluate any possible ARS symptoms and arrange for an interpret all post-PEP HIV tests. Having to take a course of PEP is indeed stressful. Having an HIV specialist involved can significantly reduce that stress. I cannot evaluate symptoms or make diagnoses over the Internet. What I can tell you is that "feeling flushed" and actually having a significant fever are two very different things. Also, even if you were to have an elevated temperature, there are many conditions other than HIV that could be the cause. I can also advise you that symptoms four days after exposure would not be related to HIV. It takes weeks, not days, for the symptoms of acute retroviral syndrome (ARS) to appear.

Dr. Bob

condom broke during the act Jan 20, 2007

First, Thank you so much for this forum.

about 4 days ago i had vaginal sex with a woman who i later discovered to be very high risk. the condom broke during our act and it was less than 3 or four minutes later that i finished. i don't know if she was hiv positive and have no way of finding out. the following day I went to the emergency room and was perscribed ATRIPLA. and of course i am not feeling very well at all on it. I go to the bathroom often and have the symptoms of a low fever at times during the day. cottonmouth, sore throat ...

I live in san francisco, and am wondering if I should have a follow up visit with a specialist in the area. And How I would find such a doctor.

Also was my risk and exposure high enough to warrant such a drastic step as ATRIPLA?

And of course I am completely freaking out that one stupid drunk moment has damaged my body to such a degree, has anyone built a time machine yet?

Response from Dr. Frascino

Hi,

Personally, I feel anyone who has had an HIV exposure significant enough to warrant a course of PEP should be followed by an HIV specialist, if possible. The HIV specialist would:

1. Evaluate the risk to see if PEP was really warranted.

2. Optimize the PEP regimen.

3. Evaluate and manage PEP-related side effects and toxicities.

4. Arrange for and evaluate post-PEP HIV testing.

Living in San Francisco, you have many options from which to choose regarding HIV specialist. Certified HIV/AIDS specialist physicians in your area can be located by consulting the American Academy of HIV Medicine Web site, www.aahivm.org.

Finally, if you do find that time machine, let me know. I know millions of folks who want to go back to 2000 and 2004 and recast their presidential vote.

Good luck.

Dr. Bob



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