Known failures of Pep with Tenofovir, 3TC, AZT
Mar 5, 2011
I know that so much has changed over the course of PEP cycles but the above mentioned combination has been becoming more popular. I wanted to know if you have any information about any reported failures with this regimen?
I know that the SF study where 7 seroconverted (6 if you don't consider the one person who actually was + a the onset) didn't use a triple drug. I also know that the data with the seroconverted lab workers were all exposed to people with AIDS and didn't have a triple drug regimen. I also only know of the monkey tests that showed that tenofovir is very effective if given within 36 hours. I also know of the french test that had zero seroconversions. SAme thing with the Boston date. I haven't been able to find a single seroconversion with this combination- has it happened?
Response from Dr. Frascino
I don't have a scientific answer for you. I'm not personally aware of any tenofovir, 3TC, AZT PEP failures; however, such failures are indeed possible. PEP is not 100% effective. The reason I can't provide a completely definitive answer for you is that there are many confounding variables associated with HIV transmission and PEP therapy. These, among many others, would include:
1. Viral strain
2. Viral load
3. Route of exposure
4. Local trauma
5. Concurrent STDs
6. Timing of first dose (the earlier PEP is taken, the more effective it is)
7. Adherence to PEP regimen
Certainly our PEP regimens have become less toxic, more convenient, better tolerated and more effective as newer and better antiretrovirals have been developed and become available. However, even in spite of these improvements, PEP failures are certainly still possible.
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Odds Of Contracting HIV Sex With Stripper
- Is Itchy Skin A Sign Of HIV?
- Is Sore Throat A Symptom Of Acute HIV Infection?
- Sex With A Prostitute How Long Does It Take To Test Positive For AIDS
- Dry Mouth After Giving Oral Sex What Are The Chances Of HIV
- Muscle Ache After Masturbation Sign Of HIV AIDS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.