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Im awaiting your response, please help another dude.
Aug 14, 2010

I have asked numerous times with no prevail.

Hope you can read/answer this for me most awesome Dr.

1.Why Do some people never make antibodies to HIV therfore they dont test positive on an antibody test.

2.If that is true (seen on this site) then there must be a reason for this occurrence. Is there any specific test someone should take if this did happen to rule out HIV, because if it happens randomly how would one know?

Thanks for reading (hopefully), i am going to donate after your response and will do so for a year every month, scouts honor~!

Response from Dr. Frascino

Hi,

1. This would be an extremely unusual and rare occurrence. It could occur in someone with a severely impaired immune system, for instance someone with agammaglobulinemia or severe common variable immunodeficiency. By the way if someone had one of these types of severe rare immune-related diseases, he would know it.

2. In the extremely rare situation where specific antibody production is known to be absent or severely deficient, a non-antibody test would be recommended. The FDA has approved the Gen-Probe ATPIMA assay (a PCR test) for HIV diagnosis. It would be useful in situations such as this.

Dr. Bob



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