|p24 present negative hiv-1 rna
May 18, 2010
I had an entire antibody test done in early january. the test came back with p24 present. Everything else was negative. The test was inconclusive and I was scared. I had a Hiv/0/2 abs-icma done which was non reactive <1.00 a negative test. Two months later I had the same antibody test done and p24 again showed up present. A RNA, real time pcr (graph) was done. Hiv-1 RNA not detected. My doctor scared me about the antibody test and I was sent to a Infection Disease Specialist.The specialist told me she didn't believe I was infected. She was unable to tell me why p24 was present. I have read that p24 is the first protein to show up. So I'm wondering if something will show up later. Just wondering if I'm ok?
| Response from Dr. Frascino
You are definitively and conclusively HIV negative. Indeterminate screening HIV-antibody tests are not uncommon and can be caused by a variety of conditions or situations. I've discussed these at length in the archives of this forum. Have a look. One of the most common causes is the presence of a cross-reacting antibody induced by a totally unrelated condition, such as pregnancy. Your follow-up tests provide overwhelming and irrefutable evidence of your HIV-negative status. Also, if your initial reactive p24 antibody was the result of early seroconversion, your follow-up test two months later would have demonstrated complete seroconversion rather than just the identical isolated p24.
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