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Budeprion XL dosing reduction

Jan 26, 2010

Dr Bob, I have recently begun having anomalies I can only directly associate with use of Budeprion XL in scattered thoughts, rash on my back, and increasing sadness/depression. In doing my own research I have found these particular issues noted on various websites regarding Budeprion side effects. Presently I take 150mg morning and 300mg afternoon. The scattered thoughts and increased depression always follow ingestion of each prescribed dose within 15 minutes. My history is encephalopathy in 2000, resolved, with motor damage to my left side and if pushed in a volley of questions I loose track mentally, otherwise in calm I can process and interact. Two years ago I slipped on ice damaging my spine / cervical compression and slight torn-bulging lumbar disc. I am recovering steadily with isometric-resistance exercises and have been prescribed diazepam 10mg 3 x daily as a muscle relaxant that helps immensly in reducing pain. I also take Nabumetone 500 mg twice daily, Reyataz 400 mg morning, Combivir twice daily, Ritalin 20 mg 3 x daily. What reduction precautions should be considered if any regarding Budeprion so that I might discuss this with some intelligence with my physician when I go in for my upcoming appointment?

Response from Dr. Frascino


I wouldn't be too quick to blame your antidepressant medication for your "increasing sadness/depression" and scattered thoughts! You report you note these symptoms "within 15 minutes" of ingestion of your prescribed dose of bupropion XL. Actually it takes much longer than 15 minutes for that medication to dissolve in your stomach, let alone get into your blood stream and begin to cause any side effects! I'd recommend you discuss your concerns with your HIV physician specialist and/or psychiatrist. Chances are there is a completely different underlying cause for your symptoms.

Good luck.

Dr. Bob

re: Why are blood donation requirements so stringent?
Not again! :(

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