|My doc told me that on treatment transmission risk is extremely low. Is he correct? (TRANSMISSION RISK WITH UNDETECTABLE VIRAL LOAD, 2009)
Dec 29, 2009
It is quite difficult to find specific answers and I was only able to find a study from Switzerland which seems very encouraging. I asked my doctor about the risks of transmission during effective HAART and he said that the risk is not zero but extremely low. He says that a certain viral load is necessary to establish infection and take hold and that an undetectable viral load would protect enough to accept the risk. He added that in his 10 years experience he never heard or is aware of a person infected from someone on treatment. Is he correct?
| Response from Dr. Frascino
"It is quite difficult to find specific answers . . . ." WHAT??? Not here it isn't. Just use the search function and you'll find very specific answers to questions you've not even thought of asking yet. Go ahead. Give it a try.
I agree with most of what your doctor told you. Specifically, I agree the risk of HIV transmission from someone on effective combination antiretroviral therapy, who has driven his HIV plasma viral load to undetectable levels, is "not zero but extremely low." I've said this repeatedly in this forum. (See the archives.)
What I don't agree with is the statement: ". . . An undetectable viral load would protect enough to accept the risk." Even with an undetectable viral load, there is still a possibility HIV transmission could occur. Safer sex (latex or polyurethane condoms for all penetrative sex) remains strongly recommended, even if someone has an undetectable viral load. (See below.)
Be well. Be safe. Stay well.
DOES size matter??? CDC FACT SHEET -- EFFECT OF ANTIRETROVIRAL THERAPY ON THE RISK OF SEXUAL TRANSMISSION OF HIV AND SUPERINFECTION, 2009) Nov 14, 2009
I'm a gay male form Vermont, 54, have been pos 22 years and finally, after all of the myriad meds, highs and lows and being brought back from the abyss in the mid 90's, have tested undetectable during the past year. It feels good. And beyond fatigue, PN in my feet and 2 shiny titanium hips, I still FEEL 'okay' and look great, (having dun bin told... :) I also have a man in my life... for the first time in awhile. The thing is, he's a big boy and has a BIG toy...so, after a dab of numbing agent, and a lot of lube, and after an ample butt-plug for 10 minutes or so, he can enter me and we have a blast...until he blasts. He's negative and after some negotiation, WE decided to forego condoms. It's fun and gooey and impetuous and I'm worried...cause having him infected would be too much to bear. So, my question to the experts is: Does the fact that I am undetectable AND as loose and non-abrasive as I can get, AND I thoroughly wash him off immediately afterward... Okay, okay, I know... but could you, would you, give me the mechanics of the nay saying??? It feels so right...(even IF 'still' a tad tight.) (Yes, Doctor Bob, I made the "tad jerky" "poster blocking" comment yesterday.) Thank you for any positive encouragement you can provide... (but if it's negative...I just KNEW you were a QUACK!!!) :)
Response from Dr. Frascino
There is no question that being on effective combination antiretroviral therapy that drives HIV plasma viral load to undetectable levels significantly decreases the risk of HIV transmission. However, and this is a very big however, it does not completely eliminate the risk. So if indeed you care about your Mr. Happily-Ever-After and the thought of infecting him is too much to bear, I urge you to follow the CDC's recommendation and use latex or polyurethane condoms for all penetrative sex. Just to prove I'm not "quacking," I'll post below the CDC's recent fact sheet on the effect of antiretroviral therapy on risk of sexual transmission of HIV infection and superinfection (from August 2009). This may not be the "positive encouragement" you were looking for, but it is the truth about having sex while being positive!
Effect of Antiretroviral Therapy on Risk of Sexual Transmission of HIV Infection and Superinfection August 2009 C
The past decade has seen substantial advances in the development of antiretroviral therapy (ART)medications used in combination to reduce the replication of HIV virus and treat HIV-infected persons. Because of these medications, many HIV-infected persons are able to reduce levels of virus in the bloodstream (plasma viral load) to undetectable levels. Data suggest that HIV-infected persons with undetectable viral load are less infectious, and may be less likely to transmit HIV via sexual contact. This fact sheet summarizes the implications of these data to individual couples and to the potential impact of ART in the prevention of HIV transmission within populations.
Prevention of Sexual Transmission of HIV: Individual Couples vs. Populations
Evidence from observational studies among heterosexual populations [1-4] and men who have sex with men (MSM)  suggests that effective ART may greatly reduce the likelihood of sexual transmission from infected individuals to their sexual partners. A study of heterosexual couples in Uganda in which one partner was infected revealed that infected persons who did transmit virus to their partners had significantly higher mean viral load than those who did not transmit (90,254 copies/mL vs. 38,029 copies/mL); no transmissions occurred among couples in which the infected partners viral load was under 1500 copies/mL . Among infected persons at a clinic in Spain , wider availability of effective ART was associated with an 80% decrease in sexual transmission of HIV . While fewer data are available regarding the impact of ART on transmission among MSM (the most affected population in the United States ), transmission rates observed among a population of MSM in San Francisco declined with the availability of ART despite increases in risk behavior, associated with an estimated 60% decrease in per-act infectivity . Mathematical modeling studies suggest that successful use of ART by enough infected individuals could substantially reduce the spread of HIV within a population [6-7]. ART thus holds promise as an important prevention tool. However, it is important to note that this potential reduction in HIV transmission within a population does not translate to elimination of transmission risk within individual couples.
What is the Risk of Sexual HIV Transmission for HIV-infected Persons With Undetectable Viral Load?
ART is considered effective when it consistently suppresses plasma viral load to undetectable levels. However, sexual transmission of HIV from an infected partner who was on ART with a repeatedly undetectable plasma viral load has been documented . An infected partner's genital (seminal or vaginal) fluid viral load may play a greater role than plasma viral load when evaluating the risk of sexual transmission of HIV. The likelihood of HIV transmission in the setting of ART is influenced by a number of factors, several of which are described below.
The Meaning of "Undetectable" Viral Load: Persistence of Virus in Plasma and Seminal Fluid
Periodic blood plasma viral load monitoring is used to measure ART effectiveness. The goal of effective ART is the long-term suppression of plasma viral load, usually defined as the maintenance of a level of HIV virus that is below the threshold detectable by available tests. While plasma viral load tests are reliable, they have limitations: virus levels below a minimum concentration may not be detected. Studies have shown that persistent virus is found in peripheral blood mononuclear cells [9, 10] even when individuals have sustained undetectable plasma viral load levels.
Genital fluid viral loads are not routinely measured in persons on ART. Although ART reduces concentration of virus in seminal fluid , virus persists within cells present in seminal fluid of some men who are on ART with undetectable plasma viral load [12-13]. ART also is associated with decrease in cervicovaginal fluid viral load; however, 'breakthrough' shedding has been observed in some studies [14-17]. Therefore, the potential for transmission exists despite sustaining undetectable viral load while on effective ART.
Transient Increases ("Blips") in Viral Load
Several studies have observed that individuals on effective ART who achieve long-term suppression of viral load to undetectable levels may exhibit periodic temporary increases in plasma viral load (blips). These are generally small increases ( between approximately 50 and 1000 copies/mL), and are estimated to last for short periods (<3 weeks) [18-20]. Because they are transient in nature, they may be missed on routine viral load testing. Currently, there are insufficient data to make statements regarding the magnitude of transmission risk related to viral load blips. However, it is conceivable that transient increases might correlate with increases in genital fluid viral load, and with enhanced sexual transmission risk.
Correlation Between Plasma and Genital Fluid Viral Load and Resistance to ART
Although ART reduces viral load in both plasma and seminal fluid, undetectable plasma viral load may not always predict undetectable seminal fluid viral load. A recent review of 19 studies, which compared plasma and seminal fluid viral loads, indicates that while blood and genital fluid viral load are often correlated, this is not always the case . Thus, a person with an undetectable plasma viral load may still shed virus in genital fluid at higher levels, which poses risk for transmission.
Several additional factors may affect genital fluid viral load. For example, sexually transmitted infections (STIs) such as gonorrhea and chlamydia have been shown to transiently increase viral load in genital fluids [22-23]. Individuals with active STIs may therefore be more infectious, despite a low or undetectable plasma viral load. Moreover, as individuals with STIs may not have any symptoms, it may be impossible for either partner to be aware of this increased risk.
Some of the variation in genital fluid viral load may be due to differences in the degree to which different ART medications enter genital fluid. Recently developed research methods allow for measurement of drug concentrations in seminal and vaginal fluids, which can then be compared to drug levels measured in blood. This research has found that some ART medications achieve higher concentrations in genital fluids than others [24-27]. For instance, nucleoside/tide reverse transcriptase inhibitors (NRTIs) penetrate to a greater extent in male and female genital secretions than do protease inhibitors (PIs). Further work of this type may eventually aid in selection of antiretroviral medications in order to reduce sexual transmission. However, more data collected via these methods and better understanding of the degree to which this approach might be effective is needed before specific recommendations can be made.
In addition to differences in viral load between plasma and genital fluids, there may also be differences in the resistance characteristics of virus in these two locations. HIV may become resistant to ART medications through mutations that occur during replication and through exposure to insufficient or inconsistent levels of HIV medications. This may happen when ART medications are not taken according to the prescribed schedule or doses are skipped. In addition, drugs which do not enter the genital fluid as well may help promote the development of resistance in the genital fluid specifically. Some researchers have noted that within an individual, the resistance characteristics of virus isolated from genital fluid may differ from those of virus isolated from plasma [28-30].
In summary, for couples in which one member is HIV-infected, treatment of the infected partner with effective ART and suppression of viral load to undetectable levels should greatly reduce the risk of transmission to the uninfected partner. However, this risk is not eliminated and it may not be maximally reduced at all times due to some of the factors discussed above. Moreover, the likelihood of transmission may be expected to increase with repeated exposures over time. In a model which estimated transmission risk in the setting of suppressed viral load (<50 copies/mL) without intercurrent STIs, the number of expected transmission events occurring within a population of 10,000 serodiscordant couples over 10 years was estimated to be 215 for female-to-male transmission, 425 for male-to-female transmission, and 3,524 for male-to male transmissions . A meta-analysis of data from 11 cohorts including 5,021 heterosexual couples observed no transmissions among persons receiving ART with a viral load of <400 copies/mL; however, analysis of the data was compatible with the possibility of one event per 70 person-years . For this reason, it is important that individual couples recognize the risk, and use additional preventive methods (e.g., condoms) in order to further minimize the chance of transmission.
ART as a Prevention Tool for Sexual Transmission of HIV
While it cannot be assumed that effective ART will eliminate transmission within individual exposures, evidence from several cohort, observational, and mathematical modeling studies suggests that effective ART may be a promising way to reduce sexual HIV transmission within populations. Potential limitations to this approach include availability of ART and appropriate monitoring, willingness of individuals to take medications, and potential offset of benefit though accompanying increases in risk behavior.
One study of the effectiveness of ART in reducing heterosexual transmission of HIV involved analysis of 393 serodiscordant heterosexual couples from 1991-2003. The authors noted that heterosexual transmission was reduced by 80% when the positive partner was treated with ART. Despite this significant reduction, the investigators cautioned against continued possible risk of transmission because of HIV levels in genital secretions of patients on ART . Among 193 discordant couples identified in the Rakai Cohort in which the infected partner had a CD4 counts under 250 cells/L, no transmission events were observed among 20 couples in which the infected partner was on ART . A study of 2993 discordant couples in Rwanda and Zambia demonstrated that ART use was associated with reduced (but not eliminated) rates of HIV transmission and reduction in unprotected sex .
Regarding potential reduction of risk within MSM populations, analysis of data from the San Francisco Young Men's Health Study evaluated transmission events among 534 MSM. The investigators found a 60% decrease in HIV transmission after the introduction of ART. The reduction occurred despite the increases in reported number of risky sexual behaviors .
Other information regarding the potential population-level benefit of ART on transmission comes from mathematical modeling studies. Mathematical models involve the development of equations to explain the relationship between the potential effects of ART on viral load and the likelihood of HIV transmission. Modeling can help predict population-level outcomes such as rate of drug resistance, rate of HIV infection or prevalence of infection, and effects of HIV treatment and prevention programs in various settings . Modeling methods are useful tools, but are limited by the fact that models reflect current understanding of how HIV is transmitted , as well as the validity of the assumptions and data used in model construction.
The potential impact of changes in risk behavior is one important determinant of the possible effect of ART in preventing transmission within a population. A model of ART use among MSM in a resource-rich setting  indicated that if treatment rates are high, transmission is likely to be significantly reduced; however, the rate of infection will be strongly influenced by changes in risk behavior, such that transmission could rise despite the increase in number treated. In a meta-analysis reviewing results of 25 studies of the impact on sexual risk behavior of ART and beliefs regarding transmissibility , being on ART or achieving an undetectable viral load was not associated with increased risky sexual behavior. However, beliefs about HIV transmission and reduced concerns about unsafe sex were associated with a greater likelihood of risky behavior.
Modeling of infectiousness of HIV-infected persons at different stages of disease suggests that persons with high viral loads associated with acute infection and end-stage disease are highly infectious; however, those with asymptomatic infection will contribute most to transmission within a population because of the longer duration of this stage . This suggests that early identification and therapy of infected persons may be an important aspect of the effectiveness of ART as a prevention tool. In a model (designed to reflect South African transmission dynamics) of a program to control heterosexual transmission which included universal voluntary HIV testing and immediate initiation of therapy in those found to be infected , incidence of new HIV cases was reduced to less than one per 1000 persons per year within a decade, and estimated deaths occurring through 2050 were estimated to be halved when compared to the current approach of waiting to start ART until a specific CD4 count is reached.
For HIV-infected individuals who are ART-nave and who have no history of AIDS-defining illness, current U.S. treatment guidelines recommend initiating ART when the CD4 count falls below 350 cells/μL in most cases . Exceptions (for whom treatment should be initiated regardless of CD4 count) include pregnant women, persons with HIV-associated nephropathy, and those co-infected with hepatitis B requiring treatment; the guidance also cites decreasing the risk of HIV transmission to others as a potential benefit to early therapy. The use of 350 cells/L as a minimum threshold is supported by analyses from a subgroup of participants from the Strategies for management of Antiretroviral Therapy (SMART) study, which noted that among persons with CD4 counts of >350 cells/L, those who were randomized to deferral of ART until the CD4 count dropped to <250 cells/L had substantially higher risk of opportunistic diseases and serious non-AIDS events relative to those who initiated ART immediately . A meta-analysis of 18 cohort studies also supports counts of 350 cells/L as a minimum threshold . Optimally, the decision to institute initiation of ART at a higher CD4 threshold on a widespread level would be based upon data from controlled studies. Recent studies indicate that initiating ART earlier than the currently recommended CD4 threshold of 350 cells/μL may confer benefits on survival  and immune function , without necessarily increasing risk of adverse events such as peripheral neuropathy, anemia, and renal insufficiency . An ongoing randomized controlled study, HIV Prevention Trials Network (HPTN) 052, will compare the effectiveness of two treatment strategies in preventing the sexual transmission for HIV. Discordant couples will be randomized to either immediate ART for the infected partner, or deferral of ART until the CD4 count falls to between 200-250 cells/L .
When Both Partners are Infected: What is the Significance of Superinfection in HIV Transmission?
Superinfection is defined as infection by a second strain of HIV after initial infection by a primary strain has been established . The frequency and timing of superinfection may vary depending upon the population under study and the method of detection. Follow-up of 78 newly infected individuals (none of whom initiated ART while under study) in one clinic revealed that 4 (5%) had acquired a superinfecting strain within 6 to 12 months of initial infection . In a cohort of 36 high-risk Kenyan women screened for HIV-1 superinfection over a 5-year period beginning at primary infection, seven cases of superinfection were detected . In this study superinfection occurred throughout the course of the first infection: during acute infection in two cases, between 1-2 years after infection in three cases, and as late as 5 years after infection in two cases. The clinical consequences of superinfection for an individual vary, but may include accelerated disease progression and the acquisition of drug resistance . The public health consequences of HIV superinfections are unclear. While superinfection can result in recombination between genetically different viruses, and a number of circulating recombinant forms (CRFs) are prevalent in certain geographic areas , it has not been demonstrated that such recombination results in the establishment of more transmissible or virulent viruses. There is also evidence that superinfection occurs only rarely in HIV-infected individuals on effective ART [49, 50] .
CDC Guidance on ART and its Effect on Sexual Transmission of HIV
Use of ART may be a promising tool for slowing the transmission of HIV within populations if prevention benefits are not offset by increases in risk behavior. Success of such a program will depend critically upon 1) widespread testing and early identification of infected persons, 2) ongoing counseling to support maintenance of safer sexual behaviors , 3) adequate clinical follow-up to monitor for adverse effects of ART, and 4) geographic and financial accessibility of treatment for affected persons. In accordance with U.S. Department of Health and Human Services guidelines , clinicians may consider the potential benefit of decreased risk of HIV transmission to others in deciding whether to initiate ART in infected patients (even at CD4 counts of >350 cells/μL). The risk of sexual HIV transmission is substantially reduced for individual couples in which the infected partner is on effective ART and has achieved undetectable plasma HIV viral load, but is not completely eliminated. Sexual transmission of HIV may still occur when the infected partner is on effective ART. In February 2008, CDC issued a statement reiterating its previous recommendations  that people living with HIV who are sexually active use condoms consistently and correctly with all sexual partners . For couples in which both partners are infected, the potential implications of superinfection are unclear. Use of condoms is recommended in this setting as well.
Quinn TC, Wawer MJ, Sewnkanbo N, et al. for the Rakai Project Study Group. Viral Load and heterosexual transmission of human immunodeficiency virus type-1. NEJM 2000;342:921-929 Castilla J, del Romero J, Hernando V, Marincovich B, Garcia S, Rodriguez C. Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV. JAIDS 2005;40:96-101. Reynolds S, Makumbi F, Kayaagi J, et al. ART reduced the rate of sexual transmission of HIV HIV-discordant couples in rural Rakai , Uganda . Abstract 52a, 16th Conference on Retroviruses and Opportunistic Infections , Montreal , February 8-11, 2009. Sullivan P, Kayitenkore K, Chomba E, et al. Reduction of HIV transmission risk and high risk sex while prescribed ART: Results from discordant couples in Rwanda and Zambia . Abstract 52bLB, 16th Conference on Retroviruses and Opportunistic Infections , Montreal , February 8-11, 2009. Porco TC, Martin JN, Page-Shafer KA, et al. Decline in HIV infectivity following the introduction of highly active antiretroviral therapy. AIDS 2004;18:81-88. Blower SM, Gershengorn H, and Grant R. A tale of two futures: HV and antiretroviral therapy in San Francisco . Science 2000 Jan 28; 287: 650-654. Granich RM, Gilks CF, Dye C, DeCock KM. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for eliminating HIV transmission: a mathematical model. Lancet 2009;373:48-57. Sturmer M, Doerr HW, Berger A, Gale P. Is transmission of HIV in non-viraemic serodiscordant couples possible? Antivir Ther 2008;13:729-732. Ibanez A, Puig T, Elias J, Clotet C, Ruiz L, Martinez M-A. Quantification of integrated and total HIV-1 DNA after long-term highly active antiretroviral therapy in HIV-1 infected patients. AIDS 1999;13:105-109. Furtado MR, Callaway DS, Phair JP, et al. Persistence of HIV-1 transcription in peripheral blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl I Med 1999;340:1614-1622. Vernazza PL, Troiani L, Flepp MJ, et al. Potent antiretroviral treatment of HIV infection results in suppression of the seminal shedding of HIV. AIDS 2000;14:117-121. Zhang H, Dornadula G, Beumont M, et al. Human immunodeficiency virus type 1 on the semen of men receiving highly active antiretroviral therapy. N Engl J Med 1998;339:1803-1809. Barroso PF, Harrison LH, de Fatima Melo M, et al, Adherence to antiretroviral therapy and persistence of HIV RNA in semen. JAIDS 2003;32:435-40. Cu-Uvin S, Caliendo AM, Reinert S, et al. Effect of highly active antiretroviral therapy on cervicovaginal HIV-1 RNA. AIDS 2000;14:415-421. Cu-Uvin S, Snyder B, Harwell JI, et al. Association between paired plasma and cervicovaginal lavage fluid HIV-1 levels during 36 months. J Acquir Immune Defic Syndr 2006;42:584-57. Fiore, JR, Suligoi B, Saracino A, et al. Correlates of HIV-1 shedding in cervicovaginal secretions and effects of antiretroviral therapies. AIDS 2003;17(15):2169-76. Neely MN, Benning L, Xu J et al. Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. JAIDS 2007; 44(1):38-42. Di Mascio M, Markowitz M, Louie M, et al. Viral blip dynamics during highly active antiretroviral therapy. J Virol 2003;77:12165-12172. Nettles RWE, Kieffer TL, Kwon P et al. Intermittent HIV-1 Viremia (blips) and drug resistance in patients receiving HAART. JAMA 2005;293:817-829. van Sighem A, Zhang S, Reiss P, et al. Immunologic, virologic, and clinical consequences of episodes of transient viremia during suppressive combination antiretroviral therapy. J Acq Immune Defic Syndr 2008;48:104-108. Kalichman SC , Di Berto G, Eaton L. Human immunodeficiency virus viral load in blood plasma and semen: review and implications of empirical findings. Cohen M, Galvin S. The role of sexually transmitted diseases in HIV transmission. Nat Rev Microbiol 2004;2:39-41. Cohen MS, Hoffman IF, Royce RA, et al, for the AIDSCAP Malawi Research Group. Reduction of concentration of HIV-1 in semen after the treatment of urethritis: Implications for prevention of sexual transmission of HIV-1. Lancet 1997;349;1868-73. Kashuba AD, Dyer JR, Kramer LM, et al. Antiretroviral drug concentrations in semen: implications for sexual transmission of HIV-1. Antimicrob Agents Chemother 1999;43:1817-26. Vergara TR, Estrela RC, Suarez-Kurtz G, et al. Limited Penetration of Lopinavir and Ritonavir in the Genital Tract of Men Infected with HIV-1 in Brazil . Ther Drug Monit 2006;28:175179. Dumond JB, Yeh RF, Patterson KB, et al. Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis. AIDS 2007;21(14):1899-907. Min SS, Corbett AH, Rezk N, et al. Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations n the genital tract of HIV-1 infected women. JAIDS 2004;37:1577-1580. Bryn RA, Kiessling AA. Analysis of human immunodeficiency virus in semen: indications of a genetically distinct virus reservoir. J Reprod Immunol 1998;41:161-176. Kiessling AA, Fitzgerald LM, Zhang D, et al. Human Immunodeficiency virus in semen arises from a genetically distinct virus reservoir. AIDS Res Hum Retroviruses 1998;14(Suppl. 1):S33-41. Eyre RC, Zheng G, Kiessling AA. Multiple drug resistance mutations in human immunodeficiency virus in semen but not in blood of a man on antiretroviral therapy. Urology 2000;55xvii-xx. Wilson DP, Law MG, Grulich AE, Cooper DA, Kaldor JM. Relation between HIV viral load and infectiousness: a model-based analysis. Lancet 2008;372:314-320. Attia S, Egger M, Müller M, Zwahlen M, Low N. Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS 2009; electronic publication ahead of print, April 17, 2009. Blower S, Volberding, P. What can modeling tell us about the threat of antiviral drug resistance. Current Opinion in Infectious Diseases 2002;15:609-614. Culshaw, R. Mathematical modeling of AIDS progression: limitations, expectations, and future directions. Journal of American Physicians and Surgeons 2006;11:101-105. Crepaz N, Hart TA, Marks G. Highly active antiretroviral therapy and risk behavior: a meta-analytic view. JAMA 2004;292:224-236. Hollingsworth TD, Anderson RM, Fraser C. HIV-1 transmission by stage of infection. J Infect Dis 2008;198:687-93. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. November 3, 2008. Accessed June 24, 2009 (Page 20). Strategies for Management of Antiretroviral Therapy (SMART) Study Group, Emery S, Neuhaus JA, Phillips AN, et al. Major clinical outcomes in antiretroviral therapy (ART)-nave participants and in those not receiving ART at baseline in the SMART study. J Infect Dis 2008; 197:1084-1086. When to Start Consortium. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 19 HIV cohort studies. Lancet 2009; 373:1352-63. Kitahata MM, Gange SJ, Abraham AG, et al for the NA-ACCORD Investigators. Effect of early versus deferred therapy for HIV on survival. N Engl J Med 2009 (E-publication ahead of print, 1 April 2009). Robbins GK, Spritzler JG, Chan ES, et al for the AIDS Clinical Trials Group 384 Team. Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin Infect Dis 2009;48:350-61. Lichtenstein KA, Armon C, Buchacz K, et al for the HIV Outpatient Study (HOPS) Investigators. Initiation of antiretroviral therapy at CD4 cell counts >/=350 cells/mm3 does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency. J Aquir Immune Defic Synd 2008;47:27-35. HIV Prevention Trials Network. HPTN052 Study Information. (accessed 5 April 2009). Smith DM, Richman DD, Little SJ. HIV superinfection. J Infect Dis 2005;192:438-444. Smith DM, Wong JK, Daar ES, Richman DD, Little SJ. Incidence of HIV superinfection following primary infection. JAMA 2004;292:1177-78. Piantadosi A, Chohan B, Chohan V, McClellan RS, Overbaugh J. Chronic HIV infection frequently fails to protect against superinfection. PLoS Pathogens . 2007 Nov;3:1745-1760 Streeck H, Li B, Poon AF, et al. Immune-driven recombination and loss of control after superinfection . J Exp Med 2008;205:1789-96. Los Alamos National Laboratories HIV Sequence Databases. The circulating recombinant forms. Accessed June 22, 2009. Chakraborty B, Valer L, De Mendoza C, Soriano V, Quinones-Mateu RE. Failure to detect human immunodeficiency virus type 1 superinfection in 28 HIV-seroconcordant individuals with high risk of reexposure to the virus. AIDS Res Hum Retroviruses 2004;20:1026-31. Gonzales MJ, Delwart E, Rhee SY, et al. Lack of detectable human immunodeficiency virus type 1 superinfection during 1072 person-years of observation. J Infect Dis . 2003 Aug 1;188:397-405. Centers for Disease Control and Prevention. Incorporating HIV prevention into the medical care of persons living with HIV: recommendations of CDC, the Health Resources and Services Administration, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR 2003;52(No. RR-12): 1-24. Centers for Disease Control and Prevention. CDC underscores current recommendation for preventing HIV transmission. February 1, 2008. Accessed June 22, 2009.
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.