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PrEP trials

Jul 30, 2009

There are ongoing trials to understand if PrEP or the assumption of antiretrovirals prior to sex could be protective to the negative partner. Currently we don't enough data to say it's safe but if a positive person is undetectable and his negative partner takes HAART using it as PrEP would this put the risk of transmission very close to zero and to a negligible point? There are many doctors who are encouraging on this subject and they also rely on the swiss study. This could be an option for magnetic couples willing to conceive naturally. Do you agree?

Response from Dr. Frascino


As you mention the PrEP clinical trials are underway and we don't have firm scientific data regarding efficacy and safety yet. However, certainly it makes sense theoretically that PrEP would decrease the risk of HIV transmission among magnetic couples, although it most likely won't completely eliminate it. Some HIV specialist are offering the PrEP option to their magnetic couples with full disclosure that we do not yet have scientific proof it really works!

Could this be used as a harm-reduction strategy for magnetic couples who want to conceive naturally? Yes, theoretically it could and is being used in some instances.

We have established that driving the HIV plasma viral load to undetectable levels with combination antiretroviral therapy significantly decreases the risk of HIV transmission. You can read more about harm-reduction strategies for magnetic couples, including pregnancy-related concerns, in the archives. Check them out!

Good luck.

Dr. Bob

Tests trump symptoms,symptoms trump tests...?
When to start meds -- very low initial viral load test

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