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CVID / PCR-DNA / P24
May 25, 2009

Dr Bob,

I have quite severe CVID, and through reading your archives am aware that this could cause a false negative with an ELISA test. As such, I took a DNA-PCR & P24 (the latter as a DUO test with ELISA) test - both negative on two occassions, several months apart.

My question is this - I am unable to find any info on the DNA-PCR's ability to detect CRFs. I live in Europe where there are more genetic variations than in the US.

I know it may depend on the test used, but I'm quite nervous about this and no one at the clinic I attended seems able to help - ie. you deal with a general std Dr unless diagnosed positive.

The result report (for the DNA) reads as follows

HIV-1 ENV proviral DNA (gp41 specific, Group M, A-H, & O) Not detected.

HIV-1 LTR proviral DNA (LTR region, Group M, A-H, & O) Not detected.

HIV-1 gag proviral - Not detected.

HIV-1 pol proviral - Not detected.

My common sense would tell me that there would be a crossover in DNA, but I'm obviously no expert!

Thanks a million!

Response from Dr. Frascino

Hi,

You are correct: Since CRF are in essence combinations of various subtypes, there is indeed homology (genetic overlap). At this point you've had the most sophisticated testing available and I would advise you believe the results. You are HIV negative.

To avoid this conundrum in the future, just be sure to never put yourself at risk!

Be well. Be safe. Stay well.

Dr. Bob



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