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Negative ELISA, and indeterminate/positive WB; Blade Runner
May 12, 2009

Dear Dr. Bob:

I really appreciate your efforts. After reading many medical papers (contradictory for me), I found my hope in your thoughts (aka site). I've spents many night surfing the web to hide my fear and anxiaty for a year. Sometimes I feel, that I cannot go further. The good thing is that I reflected more in the first months than in all my life (even most of my friends say that I'm over sensible). But after many I, I, I, YOUR answers brought my light and hope (and humor). Dear Dr. Bob... THANKS for your courage.

Even I read your posts, I feel like I'm in a confusion zone, in a fissure of the system.

I can send you the detailed table, if you do not post it.

TEST RESULTS

Month 0; I had a ELISA reactive test. Month 1.5; WB: indeterminated,(p66: POSITIVE WEAK) Month 4; WB: indeterminated, (p24: POSITIVE); Month 6; WB: indeterminated (p24: POSITIVE); Viral load: undetectable; Month 10; WB: indeterminated (p24: POSITIVE, p40: INDETERMINATED); Viral load: undetectable; Month 13; WB: POSITIVE (p24: POSITIVE, gp41: POSITIVE, p55: INDETERMINATED); Viral load: undetectable;

Except for the first ELISA reactive, other ELISAs have been negatives

By the way, I've been tested 8 times through 13 months. I have negative tests: HVC, HBsAg, VDRL, ACS Anti-HIV, Electro Quimio Luminiscence, PCR (and others).

I have a stable couple, the most risky thing since Month 0, was that I did a oral sex (not swallow) in Month 1.5 (I though I was clean, silly I am) and one protected penetration. Two months before I had unprotected sex with a ocassional women (I regret from this, because as far as I know that is high risk behaviour).

CONFUSION

I read in: http://www.thebody.com/Forums/AIDS/SafeSex/Archive/Infected/Q196291.html "Beyond the "window period," ELISA tests are very rarely "false negative." This means if you have a negative test result, and you were tested at least six months after the last potential exposure, you are really HIV negative."

more below: "False positive results are extremely rare with the WB, so it confirms (proves) that HIV antibodies are present. "

http://www.thebody.com/Forums/AIDS/SafeSex/Archive/Testing/Q157543.html MY HOPE "A positive Western Blot does not "override" a negative ELISA, because a Western Blot should never even be performed unless there is a positive ELISA to begin with so in essence there isn't anything to over ride in the first place."

Because my common testing results are negative ELISA, and indeterminate/positive WB, I'm confused

QUESTIONS

=================================================== 1. Am I more likely to be? (MOST IMPORTANT QUESTION) (a) Definitely Positive (b) In a seroconversion process (therefore Definitely Positive) (c) Continue testing for ___ months (d) Have an immune disease (like which?) (e) Enoughly clean to have babies (by normal intercourse, not in vitro) (f) Definitely Negative ====================================================

2. If you consider that I am not positive:

- To whom or where should I refer to my doctor? I mean, where he can be convinced that I am not positive? - I have a VAGUE remember that I was just finished from a flu, but I was asked like 6-8 months later, so I'm far to be sure, (should I go with a hypnothic professional to remember this?) - Should I still be under testing?

If you consider that I am positive: - Approximately in how many months I should expect to start medication?

I want to learn from your example. In "Blade Runner", the only difference between androids and humans was the compassion: after watching violent news and films, you reinforce our human kind. Thanks Bob, EPI

Response from Dr. Frascino

Hi EPI,

Your results are somewhat confusing. For unclear HIV-antibody test results I recommend getting a qualitative HIV DNA PCR test. This test, although not approved or recommended for routine HIV diagnostic screening, can be very helpful in sorting out disputed or unclear HIV-antibody test results. PCR testing does not rely on anti-HIV antibodies but rather detects a piece of the virus's genetic material.

Responding to your specific questions:

1. I would say there is still a very good chance you are HIV negative. You've had five negative ELISA tests out 13 months since your initial reactive ELISA test. Western Blot tests should not be run if you have a negative ELISA.

2. Refer your doctor here, if he needs information. Hypnosis is not needed. My testing recommendation is detailed above.

Good luck! Write back and let us know the final result.

Dr. Bob



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