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core antibody

Apr 7, 2009

Dear dr Frascino, I recently read to cdc article about seroreversion.I have a question.Is it possible to lose your core-antibody without being symptomatic?

I am someone who tested negative 6 months after her possible exposure.

Eve , from Greece P.S.: please continue the best work I've ever seen on the net.Your site is awesome

Response from Dr. Frascino

Hi Eve from Greece,

I'm not exactly sure what you read but HIV-antibody screening tests test for a variety of specific anti-HIV antibodies against both core and envelope proteins. Generally speaking if someone is HIV infected they would not "lose" specific core antibodies. I'll reprint below some information from the archives that addresses this topic.

One thing is absolutely certain: Your six-month negative HIV test is definitive and conclusive. HIV is not your problem. No way. No how! OK?

Stay well.

Dr. Bob

Re-CORE ANTIBODY!!??? Feb 10, 2007

Hey there bob sorry about your loss. So sad. I too have lost my brother and my sister just a couple years ago so my heart aches for you. I was reading your archives about the indeterminate wb date 2/8 and I was wondering if I had hiv test 9 yrs after exposure (oraquick) would it come out negetive due to waiting so long that i am in the late stages of hiv and have lost my core antibodies. This really made me question my results as many people who read that are thinking the same thing. But if not then "WHHHHHHOOOOHOOOOO" right? My 20 min test is correct. Please clear this up I am so confused!!!! Great job on al your hard work and whitty answers. You are FABULOUS!!!!! Donation on it's way do you except paypal? love, wannabe ww

Response from Dr. Frascino


You no longer have to be a "wannabe." You are now a Dr. Bob-certified WOO-HOOer, OK? Your negative OraQuick nine years after a potential exposure is definitive and conclusive. HIV is not your problem. No way. No how!

The loss of an anti-HIV antibody due to late-stage illness is the result of profound immunodeficiency essentially the collapse of the immune system! If and when that occurs, the patient would be extremely ill with end-stage AIDS. Obviously this is not the case with you! So yell WOO-HOO and let's get this party started!

Regarding donations to The Robert James Frascino AIDS Foundation, sure, we accept PayPal and just about any other type of monetary gift as well. Details are available on the Foundation's Web site at Just click on the "Donate" tab. You can also view our latest foundation newsletter by clicking on the "News" tab.

Be well. Stay well.

Dr. Bob

one more same question about testing

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