|HIV/AIDS Resistance Gene (DELTA 32 mutation)
Mar 25, 2009
In my contemporary biology class, we heard about a gene found in males of Northern European descent that has HIV/AIDS resistant properties. My family is very Irish (my last name is Sullivan), and I was wondering not only if this is true, but if there was a way I could get check for it.
| Response from Dr. Frascino
I believe what you are referring to is the delta 32 gene mutation. See below.
Had unprotected sex with a guy who has ccr5 delta 32 (DELTA 32) Oct 13, 2008
Last night I had unprotected sex with a guy who claims that he has ccr5 delta 32 and got a negative HIV test recently. I'm worried about it as his ex is positive. My question is do people who have ccr5 delta32 carry HIV? Is the risk of me getting HIV low? Shall I take pep or go to get a test? Thanks a lot!!
Response from Dr. Frascino
Even if a guy strapped a lie detector on his Mr. Happy, I wouldn't believe claims that unsafe sex is not risky, because your partner states he's "delta 32." I'll reprint below some information from the archives pertaining to delta 32.
Your HIV-acquisition risk should be considered the same as that of anyone else who elected to have unprotected sex. PEP would only be recommended if your partner was confirmed to be HIV positive (or strongly suspected of being HIV positive) and if you had a significant exposure. I can't tell from your question what type of "unprotected sex" you had with Delta-Dude, but I doubt PEP would be warranted. Testing, however, at the three-month mark is warranted. I urge you to reconsider your decision to place yourself at risk for STDs, including HIV, by barebacking.
Be safe. Be well.
No HIV in 8 years (DELTA 32) Nov 1, 2007
To Whom It May Concern:
Thank you for your time in reading this. I am writing to ask a question. A good friend of mine is a homosexual male. I have personal knowledge that my friend has had receptive anal sex with over 1,500 men over the past 8 years. My friend frequents hot spots in local parks and public restrooms, and finds sexual partners on the internet. According to my friend (and I find this information credible), over 90% of his sexual encounters were unprotected and most of these men have ejaculated into his rectum. Some of the men who have ejaculated in my friends rectum are HIV positive.
Notwithstanding the fact that my friend has had unprotected sex with this many men, a recent HIV test was negative.
Having had unprotected anal sex this many times and with some known HIV-positive men, why hasnt my friend become HIV positive? Is there anyone, perhaps a research institute, who would be interested in a blood sample of my friend for further analysis? It seems like somebody would be collecting this type of data.
Thank you so much in advance for your response,
Concerned with finding a cure as fast as possible
Response from Dr. Frascino
Thanks for your post and interest in helping to find a cure as fast as possible.
If your story about your friend is indeed accurate, he is one lucky boy. He's also a boy with significant psychological issues who is courting disaster with his self-destructive and irresponsible behavior. I'm quite amazed he found 1,350 guys (90% of 1,500) willing to have unprotected anal sex with him. Is he a closeted Republican Congressman or clueless rightwing religious zealot perchance? Oh, never mind. Is it possible he could have avoided infection, despite his activities at the hot spots? Yes, it is. Not every HIV exposure leads to HIV infection. Thankfully! Your friend might even have some genetic predisposition against HIV infection. (See below.) The bottom line, however, is that he's putting his bottom at risk with every unprotected poke he gets and sooner or later he's going to lose the STD/HIV sexual Russian roulette game big time. My advice is that you try to convince your good friend he needs help. We don't need his blood, but he definitely needs counseling and a change in behavior ASAP.
HIV+ Resistant Sep 12, 2007
Six month after he left me, My boyfriend send me a letter to tell me he had been tested positive and had developped aids. We had been together for two and a half years. We had unprotected sex many times, almost daly. He thinks he was infected throughout our relationship. I received loads from him in my mouth as much as in my ass. I got tested when I received his letter and was diagnosed negative. I got tested every year since then and still negative. It has been five years now and I have had other relationship with many partners. Is it possible that I am immune against the virus. That my body is protected against it. Is there a test we can take to see if our immune system can fight the virus on its own. If so where can I take such a test. I live near Montreal in Quebec, Canada. Thanks for your time. Cheers, Eric
Response from Dr. Frascino
Are you immune to HIV? No, most likely not. What you are is damn lucky! I urge you not to push your luck by assuming you are immune. That's playing sexual Russian roulette and ultimately you will lose.
I will reprint below some information from the archives concerning the Delta 32 mutation. This is an evolving story. Even with the mutation you would not be immune to all types of HIV.
Stay safe. Stay well.
delta 32 Mar 17, 2007
Dr. Bob ...
I think I may have heard everything now! So, I'm on Craigslist just 'poking' around and I see this guy who wants to have sex - but, he only does it bb. Now, here is where it gets wacky! He's HIV Negative and says, "I just got tested in January, but, I just do that so guys will know the right answer. I don't worry about HIV ... I'm delta 32."
What does that mean? I went to a link, that he provided, and it talked about smallpox, and the plague.
What gives? Is this guy a bit crazy or is he really "safe?"
Can you shed some light, my friend?? :)
Thanks!! Oh and P.S., I thought I found Prince Charming ... But, it wasn't him! I'm still looking! You have any cute friends in Orange County?
Response from Dr. Frascino
So you were poking around Craigslist looking for some poking?
Delta 32 is a bit complex to explain, but I'll give it a shot. First, some background. HIV can only infect certain cells that have specific "receptors" on their surface that allow HIV to enter. HIV attaches to CD4 receptors. However, CD4 alone isn't enough for viral entry. Another protein called CCR5 is also needed. CCR5 is called a co-receptor. Some folks have a mutation in the CCR5 gene called CCR5-delta 32 mutation. This mutation changes the configuration of the CCR5 protein such that HIV cannot bind to it. Genes, of course, are inherited. If you inherit a CCR5-delta 32 gene mutation from both parents, your chances of becoming HIV infected are dramatically reduced. This occurs in about 1-3% of Caucasians. If you inherit one CCR5-delta 32 mutation (from just one parent), it will confer some protection against acquiring HIV and may make HIV disease less severe if you do become infected. Current estimates are that 10-25% of Caucasians may have a single CCR5-delta 32 mutation.
So should Craigslist Delta-32 Boy "not worry" about HIV? Absofrickinlutely NOT! It is downright dangerous to assume you are safe if you have the CCR5-delta 32 mutation. It is not a guarantee of HIV immunity. HIV is much too smart for that. Some strains of HIV use proteins other than CCR5 as co-receptors to enter CD4 cells.
As for the bubonic plague (Black Death) and smallpox link, it appears that the CCR5-delta 32 mutation may have arisen to protect folks in Europe from these illnesses. The mutation affords protection from these ailments and could have arisen via an evolutionary process. (Yes, right-wing religious wing-nuts, evolution does indeed exist!)
So if you happen to hook up with Delta-32 Boy, you might want to give him a science lesson along with his poke.
Finally, hotties in Orange County? Sure, I know some Prince Charmings in that zip code, but unfortunately none are currently single. So I guess you'll just have to continue kissing those toads until your prince arrives.
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