|HIV can even penetrate healthy genital tissues? This article says so..
Dec 19, 2008
Hi Dr Bob,
Hope you are doing well. I found this article in the newspaper today.
Chicago: Instead of infiltrating breaks in the skin, HIV appears to attack normal, healthy genital tissue, US researchers said in a study that offers new insight into how the AIDS virus spreads. They said researchers had assumed the human immunodeficiency virus, or HIV, sought out breaks in the skin, such as a herpes sore, in order to gain access to immune system cells deeper in the tissue. Some had even thought the normal lining of the vaginal tract offered a barrier to invasion by the virus during sexual intercourse. Normal skin is vulnerable, said Thomas Hope of Northwestern Universitys Feinberg School of Medicine said. It was previously thought there had to be a break in it somehow, said Hope, who is presenting his findings at the American Society for Cell Biology meeting in San Francisco. He said until now, scientists had little understanding of the details of how HIV is transmitted sexually in women. Hope and colleagues at Northwestern in Chicago and Tulane University in New Orleans developed a new method for seeing the virus at work. They studied vaginal tissue taken from hysterectomy surgeries, and introduced the virus which carried fluorescent, light-activated tracers. Then they watched under a microscope as the virus penetrated the outer lining of the female genital tract, called the squamous epithelium. They also observed this same process in non-human primates. In both cases, they found HIV was able to quickly move past the genital skin barrier to reach immune cells, which the virus targets. Hope said the study suggests the virus takes aim at places in the skin that had recently shed skin cells, in much the same way that skin on the body flakes off. The finding casts doubt on the prior theory of the virus requiring a break in the skin or gained access through a single layer of skin cells that line the cervical canal. And it might also explain why some prevention efforts have failed. Hope said one clinical trial in Africa in which women used a diaphragm to block the cervix had no effect at reducing transmission of HIV. AGENCIES.
Let us know your thoughts on this. Wishing you the best of health.
| Response from Dr. Frascino
This is new and very preliminary information. Stay tuned to The Body. We'll keep you informed as this story evolves or dissolves!
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.