Why PEP affects the window period?
Jun 20, 2008
Hi Dr. Bob! I have noticed that when somebody ask you about the window period or the reliability of a ELISA after 3 months you say is ok, but if this person took the PEP, a 3 months negative is a extremely encouraging finding but not conclusive until the 6 months negative result. Or is it because to justify a PEP risk is much higher and must wait 6 months for a conclusive result? Does a PEP affects the reliability off an antibody test? In advance thank you very much! Andres.
Response from Dr. Frascino
PEP should only be recommended for individuals who have had a very significant HIV exposure. The CDC recommends an additional HIV test at the six-month mark in addition to the usual three-month test for folks who have had a significant HIV exposure. The published guidelines for PEP and nPEP (non-occupational post-exposure prophylaxis) recommend post-PEP HIV testing at both three and six months. You can download a copy of the recommendations at http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5402a1.htm.
Hopefully this clears up any confusion in my responses.
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