Jun 3, 2007
First I want to thank you for taking time out of your busy life to answer my question. I am a sexually active male that practices safe sex, therefore considered "low risk". After an annual HIV test I received an "indeterminate" test result, weakly reactive p24 on both Elisa/WB. After taking a second test one month later the results were unchanged. I spoke with a doctor who explained to me that just about everyone who has an "indeterminate" WB due to seronconversion will go on and convert within one month. I was told in all likelihood this is a "False Positive" result. I decided it was in my best interest for yet another HIV test this happened to be five and a half months out from my initial "indeterminate" result. Guess what the result was? I'll save you the suspense...same result. I'm sure you now understand why I am so confused. Would you recommend I take a fourth Elisa/WB test that would put me a little beyond this six month mark the CDC recommends? Should I request a viral load test or do I accept the fact that I am HIV negative with three serve anxiety causing test results?
Response from Dr. Frascino
The most important factor in evaluating indeterminate results is risk assessment. Folks like you in low-risk categories who have indeterminate tests are almost never infected with either HIV-1 or HIV-2. In some cases yours, for instance repeat testing may continue to show indeterminate results and the exact cause for this unusual pattern of testing remains unknown. I agree with your doctor: folks with indeterminate tests who are in the process of seroconverting will have a positive Western Blot within one month. I would recommend a DNA PCR in situations like yours to provide absolute assurance, not to mention piece of mind. I'm confident you are indeed HIV negative.
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